Glycoside constituents of Camellia amplexicaulis and their α-glucosidase inhibitory activity

  • Nat Prod Res. 2024 Feb-Mar;38(5):759-767. doi: 10.1080/14786419.2023.2196724.
Nguyen Thi Cuc  1 ,  Duong Thi Dung  1 ,  Ngo Anh Bang  1 ,  Duong Thi Hai Yen  1 ,  Nguyen Huy Hoang  1 ,  Phan Van Kiem  1  2 ,  Bui Huu Tai  1  2
Affiliations
  • 1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
  • 2. Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi, Vietnam.
PMID: 37005002 DOI: 10.1080/14786419.2023.2196724
Abstract

Four new glycosides, named amplexicosides A-D (1-4), and five known compounds: benzyl 2-[β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyloxy]-benzoate (5), benzyl 2-neohesperidosyloxy-6-hydroxybenzoate (6), chrysandroside A (7), chrysandroside B (8) and camelliquercetiside C (9) were isolated from the branches and leaves of Camellia amplexicaulis (Pit.) Cohen-Stuart. Their structures were elucidated using HR-ESI-MS and 1D- and 2D-NMR spectra and compared to reported NMR data. All of the isolated compounds were screened in an α-glucosidase assay. Compounds 4, 8, and 9 significantly inhibited α-glucosidase with respective IC50 values of 254.9 ± 4.2, 304.8 ± 11.9 and 228.1 ± 16.4 μM.

Keywords
Camellia amplexicaulis; amplexicoside; benzoate derivative; flavonol glycoside; α-glucosidase inhibitor.
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