Guanine-7-oxide, a novel antitumor antibiotic

  • J Antibiot (Tokyo). 1985 May;38(5):572-4. doi: 10.7164/antibiotics.38.572.
D L Kern ,  G C Hokanson ,  J C French ,  N K Dalley
PMID: 3839496 DOI: 10.7164/antibiotics.38.572
Abstract

A new Antibiotic, PD 113,876, was isolated from the culture broth of a Streptomyces sp. and was shown by X-ray diffraction analysis to be the N-7 oxide of guanine. This novel antimetabolite is very active in vivo against L1210 lymphocytic leukemia.

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