VSIG2 as a novel immunosuppressive ligand interacts with Nectin-2 to regulate T cell responses

  • J Neuroinflammation. 2025 Dec 5;23(1):11. doi: 10.1186/s12974-025-03645-7.
Xianbin Wang  #  1  2 ,  Rong Hu  #  1  3 ,  Kezhu Chen  1  3 ,  Keke He  1  3 ,  Yuandi Li  1  3 ,  Jie Gao  3 ,  Yishen Tian  3 ,  Guangshi Du  3 ,  Zuli Wang  4 ,  Youbo Zhao  5  6 ,  Laijun Lai  7 ,  Min Su  8  9  10
Affiliations
  • 1. Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 2. Department of Rehabilitation Medicine, Affiliated Hospital of Guizhou Medical University, No. 28, Guiyi Street, Yunyan District, Guiyang, Guizhou, 550001, China.
  • 3. Department of Histology and Embryology, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 4. Guizhou Province Key Laboratory of Regenerative Medicine, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 5. National Joint Local Engineering Laboratory for Cell Engineering and Biomedicine Technique, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 6. Key Laboratory of Adult Stem Cell Translational Research, Chinese Academy of Medical Sciences), Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China.
  • 7. Department of Allied Health Sciences, University of Connecticut, 1390 Storrs Road, Storrs, CT, 06269, USA.
  • 8. Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China. [email protected].
  • 9. Department of Histology and Embryology, Guizhou Medical University, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China. [email protected].
  • 10. Key Laboratory for Research on Autoimmune Diseases of Higher Education schools in Guizhou Province, 6 Ankang Avenue, Guian New District, Guizhou, 561113, China. [email protected].
  • # Contributed equally.
PMID: 41350674 DOI: 10.1186/s12974-025-03645-7
Keywords
B7 superfamily; Co-inhibitory molecules; Nectin-2; T cells; VSIG2.