Pharmacological activation of SERCA2 reverses ER calcium dysregulation and depression-like behaviors in hyperglycemic mice

  • Sci Rep. 2025 Dec 12. doi: 10.1038/s41598-025-31293-7.
Huiju Lee  1 ,  Yiseul Han  1 ,  Ju-Yeon Song  1 ,  Do Gyeong Kim  1 ,  Heekyoung Chung  1  2 ,  Sung Jun Jung  3  4  5 ,  Hyeon Son  6  7  8
Affiliations
  • 1. Hanyang Biomedical Research Institute, Hanyang University, Seongdong-gu, Seoul, 04763, Korea.
  • 2. Department of Pathology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, 04763, Korea.
  • 3. Hanyang Biomedical Research Institute, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 4. Department of Physiology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 5. College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. [email protected].
  • 6. Hanyang Biomedical Research Institute, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 7. Department of Biochemistry and Molecular Biology, College of Medicine, Hanyang University, Seongdong-gu, Seoul, 04763, Korea. [email protected].
  • 8. College of Medicine, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Republic of Korea. [email protected].
PMID: 41387522 DOI: 10.1038/s41598-025-31293-7
Keywords
CDN1163; Depression; ER stress; Hyperglycemia; SERCA2.
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