Two new polyketides isolated from the endophytic fungus Phomopsis heveicola POH-zhi and its antifungal activity

  • J Asian Nat Prod Res. 2026 Apr 10:1-8. doi: 10.1080/10286020.2026.2649829.
Rui-Han Zhang  1 ,  Yan Dong  1 ,  Yi Sun  2 ,  Yi-Hui Yang  1 ,  Chang Li  1
Affiliations
  • 1. Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Harbin 150081, China.
  • 2. Integrated Chinese Medicine Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
PMID: 41958324 DOI: 10.1080/10286020.2026.2649829
Abstract

Two new polyketides, demethyl-epiremisporine B (1) and demethyl-coniochaetone A (2), together with four known polyketide compounds including diaportheone A (3), vertixanthone (4), peniphenone (5) and 3,8-dihydroxy-1-propylanthraquinone (6), were isolated from the endophytic fungus Phomopsis heveicola obtained from Sterculia lychnophora. The structures of the new metabolites were elucidated by NMR and HRESIMS analysis, and the absolute configuration of compound 1 was established by ECD spectroscopy. These compounds were evaluated for their Antifungal activity against Candida albicans CMCC 98001 and Aspergillus niger R330. Compounds 4 and 6 showed significant Antifungal activity on C. Albicans CMCC 98001, with the MIC of 3.125 μg/ml.

Keywords
Phomopsis heveicola POH-zhi; antifungal activity; polyketide; secondary metabolites.
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