5-Iminodaunorubicin. Reduced cardiotoxic properties in an antitumor anthracycline

  • J Med Chem. 1979 Jan;22(1):36-9. doi: 10.1021/jm00187a009.
G L Tong ,  D W Henry ,  E M Acton
PMID: 423181 DOI: 10.1021/jm00187a009
Abstract

Treatment of daunorubicin with methanolic ammonia affords 5-iminodaunorubicin, the first quinone-modified analogue of either daunorubicin or adriamycin. This product retains antileukemic activity in mice, is less cardiotoxic by electrocardiographic measurements in rats, and is nonmutagenic in Salmonella typhimurium (Ames test).