Sugar derivatives and liver mitochondria. I. - Effect of methyl-3,5-di-O-benzyl-2-chloro-2-deoxy-D-arabinofuranoside

  • Res Commun Chem Pathol Pharmacol. 1979 Apr;24(1):181-95.
M Alvarez ,  J H Duarte ,  A P Campello
PMID: 432434
Abstract

Effect of fifteen sugar derivatives on oxygen uptake and Oxidative Phosphorylation by liver mitochondria were tested. Full details of the possible mechanism of action of methyl-3,5-di-O-benzyl-2-chloro-2-deoxy-D-arabinofuranoside (VI) was presented. This sugar derivative seems to act as inhibitor of the electron transport in the respiratory chain and as an uncoupler.

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