Production of a mutagen from ponceau 3R by a human intestinal anaerobe

  • Infect Immun. 1979 Mar;23(3):686-9. doi: 10.1128/iai.23.3.686-689.1979.
C P Hartman ,  A W Andrews ,  K T Chung
PMID: 457255 DOI: 10.1128/iai.23.3.686-689.1979
Abstract

Ponceau 3R was reduced in vitro by Fusobacterium sp. 2, a human intestinal anaerobe, to a product which is mutagenic when metabolically activated by liver S9 preparations in the Salmonella/mammalian-microsome mutagenicity test. This mutagenic metabolite has been identified as 2,4,5-trimethylaniline.

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