Vasopressin analogues and spatial working memory in the 24-arm radial maze

  • Peptides. 1982 Sep-Oct;3(5):725-7. doi: 10.1016/0196-9781(82)90005-5.
O Buresová ,  J Skopková
PMID: 7177919 DOI: 10.1016/0196-9781(82)90005-5
Abstract

The effect of vasopressin analogues dAVP, dDAVP, and desgly NH2 dDAVP on working memory was tested in the 24-arm radial maze in twelve 6-month-old and twelve 19-month-old rats. No age dependent effects were found. All three peptides tested (3 micrograms/kg) tended to improve the performance but only the desgly NH2 dDAVP significantly decreased the number of errors. A second application of desgly NH2 dDAVP was ineffective. The specificity of activation of memory mechanisms by desgly NH2 dDAVP can be questioned.

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