Louisianins A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. II. Physico-chemical properties and structural elucidation

  • J Antibiot (Tokyo). 1995 Oct;48(10):1090-4. doi: 10.7164/antibiotics.48.1090.
S Takamatsu  1 ,  Y P Kim ,  M Hayashi ,  K Furuhata ,  H Takayanagi ,  K Komiyama ,  H B Woodruff ,  S Omura
Affiliations
  • 1. Kitasato Institute, Tokyo, Japan.
PMID: 7490213 DOI: 10.7164/antibiotics.48.1090
Abstract

New non-steroidal growth inhibitors of testosterone-responsive SC 115 cells, louisianins A (MW: 189; C11H11NO2), B (MW: 191; C11H13NO2), C (MW: 173; C11H11NO) and D (MW: 173; C11H11NO) were isolated from the cultured broth of Streptomyces sp. WK-4028. Their structures were determined on the basis of spectroscopic data. The structure of louisianin A in particular was confirmed by X-ray crystallographic analysis. The four compounds commonly possess a unique pyrindine skeleton in the molecule.

Products