Novel microbial metabolites of the phoslactomycins family induce production of colony-stimulating factors by bone marrow stromal cells. II. Isolation, physico-chemical properties and structure determination

  • J Antibiot (Tokyo). 1993 Oct;46(10):1512-9. doi: 10.7164/antibiotics.46.1512.
T Kohama  1 ,  T Nakamura ,  T Kinoshita ,  I Kaneko ,  A Shiraishi
Affiliations
  • 1. Bioscience Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
PMID: 7503976 DOI: 10.7164/antibiotics.46.1512
Abstract

Leustroducsins (LSNs) A, B and C, novel inducers of colony-stimulating factors (CSFs), were isolated from culture broth of Streptomyces platensis SANK 60191 mainly by ethyl acetate extraction and preparative reverse-phase HPLC. The molecular weights and molecular formulae of LSNs A, B and C are 641: C32H52O10NP, 669: C34H56O10NP and 669: C34H56O10NP, respectively. The structure elucidation revealed that they belong to the phoslactomycin group Antibiotics, and their structures contain an alpha,beta-unsaturated delta-lactone, an amino group, a phosphate ester and a cyclohexane ring moiety. The structures differ only at the substituent bound to the cyclohexane ring.

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