Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica
- J Nat Prod. 1995 Jul;58(7):1032-8. doi: 10.1021/np50121a007.
Affiliations
- 1. Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan.
PMID: 7561896
DOI: 10.1021/np50121a007
Abstract
Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian Cancer cell lines with log GI50 values in the range of -4.14 to -5.72.
Products
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Cat. No.Product NameDescriptionTargetResearch Area
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target: Microtubule/TubulinResearch Areas: Cancer