Illudinic acid, a novel illudane sesquiterpene antibiotic

  • J Nat Prod. 1997 Feb;60(2):188-90. doi: 10.1021/np960596x.
C Dufresne  1 ,  K Young ,  F Pelaez ,  A Gonzalez del Val ,  D Valentino ,  A Graham ,  G Platas ,  A Bernard ,  D Zink
Affiliations
PMID: 9051915 DOI: 10.1021/np960596x
Abstract

A novel illudane sesquiterpene Antibiotic (1) with activity against methicillin-resistant Staphylococcus aureus (MRSA), has been isolated. Its MIC against MRSA was found to be 16 micrograms/mL. It also shows L-1210 cytotoxicity with an IC50 of 10-15 micrograms/mL.