New bioactive triterpenoids from Melia volkensii

  • J Nat Prod. 1998 Jan;61(1):64-70. doi: 10.1021/np9704009.
L L Rogers  1 ,  L Zeng ,  J F Kozlowski ,  H Shimada ,  F Q Alali ,  H A Johnson ,  J L McLaughlin
Affiliations
  • 1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, USA.
PMID: 9461654 DOI: 10.1021/np9704009
Abstract

Bioactivity-directed fractionation of the root bark of Melia volkensii resulted in the isolation of two new natural products, meliavolkinin (1) and melianin C (3), together with two known compounds, 1,3-diacetylvilasinin (2) and melianin B (4). Jones oxidation of 4 gave compounds 3, 23,24-diketomelianin B (5), and 16,23,24-triketomelianin B (6). The structures of the new compounds were elucidated by spectral and chemical data. Compounds 1-6 all showed marginal cytotoxicities against certain human tumor cell lines, while 5 showed selective cytotoxicities for the human prostate (PC-3) and pancreatic (PACA-2) cell lines with potencies comparable to those of adriamycin.