Glucosylquestiomycin, a novel antibiotic from Microbispora sp. TP-A0184: fermentation, isolation, structure determination, synthesis and biological activities

  • J Antibiot (Tokyo). 1998 Oct;51(10):915-20. doi: 10.7164/antibiotics.51.915.
Y Igarashi  1 ,  K Takagi ,  T Kajiura ,  T Furumai ,  T Oki
Affiliations
  • 1. Biotechnology Research Center, Toyama Prefectural University, Kosugi, Japan.
PMID: 9917004 DOI: 10.7164/antibiotics.51.915
Abstract

Glucosylquestiomycin, a novel N-glucopyranoside of questiomycin A, was isolated from the culture broth of Microbispora sp. TP-A0184. The absolute configuration of the sugar was determined as D-configuration by chemical synthesis. The new Antibiotic showed Antibacterial activity against gram-positive and -negative bacteria and yeasts and cytotoxic activity against U937 cells.

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