(Rac)-Deox B 7,4
(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity.
For research use only. We do not sell to patients.
- CAS No.: 674786-37-9
- Formula: C18H18O5
- Molecular Weight:314.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | IC50 |
30.6 μM
Compound: 3o
|
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human BT549 cells assessed as reduction in cell viability after 24 hrs by MTT assay
|
[PMID: 29074256] |
| HeLa | IC50 |
50.12 μM
Compound: 3o
|
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
|
[PMID: 29074256] |
| Vero | IC50 |
>200 μM
Compound: 3o
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 24 hrs by MTT assay
|
[PMID: 29074256] |
(Rac)-Deox B 7,4 reduces the growth and viability of all tested AML cell lines with a submicromolar IC50 (range 324-556 nM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 674786-37-9
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Molecular Weight 314.33
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Formula C18H18O5
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SMILES
O=C1C(COC2=C1C=CC(OC)=C2)CC3=CC=C(C(O)=C3)OC
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Synonyms
(Rac)-Deoxysappanone B 7,4' dimethyl ether
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)