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Art. -Nr.: HY-186206

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(Rac)-EGC-M7

(Rac)-EGC-M7 is a racemic microbial metabolite of green tea Catechin (EGC) (HY-N0898), and acts as an inhibitor of nitric oxide production and cancer cell growth. (Rac)-EGC-M7 can be used in the research of esophageal squamous cell carcinoma and colon adenocarcinoma.

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CAS. Nr.: 509078-28-8
Formel: C₁₁H₁₂O₅
Molecular Weight:224.21

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-EGC-M7 Chemical Structure

CAS. Nr.: 509078-28-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	73 μM Compound: 1	Inhibitory concentration against human colon adenocarcinoma cells, HCT116 cells (Range=15-73) Inhibitory concentration against human colon adenocarcinoma cells, HCT116 cells (Range=15-73)	[PMID: 15686878]
HT-29	IC₅₀	73 μM Compound: 1	Inhibitory concentration against human colon adenocarcinoma cells, HT-29 cells (Range=15-73) Inhibitory concentration against human colon adenocarcinoma cells, HT-29 cells (Range=15-73)	[PMID: 15686878]

In Vitro

(Rac)-EGC-M7 (Compound M4 (1)) (15-73 μM) potently inhibits the growth of human esophageal squamous cell carcinoma cell line (KYSE150), human colon adenocarcinoma cell lines (HT-29, HCT-116), immortalized human intestinal epithelial cell line (INT-407) and immortalized rat intestinal epithelial cell line (IEC-6), with IC₅₀ values ranging from 15 to 73 μM^[1].
(Rac)-EGC-M7 (20 μM) inhibits nitric oxide production by 50% in LPS (HY-D1056)-stimulated murine macrophage RAW264.7 cells, with no effect on arachidonic acid release^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS. Nr. 509078-28-8
Molecular Weight 224.21
Formel C₁₁H₁₂O₅
SMILES

O=C1OC(CC1)CC2=CC(O)=C(C(O)=C2)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Lambert JD, et al. Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives. Bioorg Med Chem Lett. 2005;15(4):873-876. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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