(±)-α-Tocopherol acetate
Based on 1 Customer Validation
(±)-α-Tocopherol acetate ((±)-Vitamin E acetate), is a orally active synthetic form of vitamin E. (±)-α-Tocopherol acetate is the ester of acetic acid and α-tocopherol. (±)-α-Tocopherol acetate can be used for the research of the susceptibility of farmed fish to infectious diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Assay : 98.69%
- CAS No.: 7695-91-2
- Formule: C31H52O3
- Masse moléculaire:472.74
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vivo
(±)-α-Tocopherol acetate (oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d, 30 d and 45 d) stimulates the seabream's non-specific immune system after 30 days of administration in the diet (1200 mg/kg)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Gilthead seabream (Sparus aurata L.)[1]
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Dosage:600 mg/kg, 1200 mg/kg, 1800 mg/kg
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Administration:oral; 600 mg/kg, 1200 mg/kg, 1800 mg/kg; 15 d,30 d and 45 d
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Result:Had a positive correlation with serum α-tocopherol levels and the increase being linked to both the dosage and length of use.
Showed no enhancement in any of their immune parameters, while those fed the diet supplemented with 1200 mg/kg presented a slightly higher (but not statistically significant) specific growth rate than fish fed the other diets.
Enhanced the serum haemolytic activity and the phagocytosis of head-kidney leucocytes by the dietary intake of 1200 mg/kg after 30 and 45 days, although leucocyte migration and respiratory burst activity remained unaffected.
Provoked no immunostimulation in 1800 mg/kg.
Chemical Information
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CAS No. 7695-91-2
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Appearance Viscous Liquid
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Masse moléculaire 472.74
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Formule C31H52O3
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Color Colorless to light yellow
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SMILES
CC(C)CCCC(C)CCCC(C)CCCC1(C)CCC2=C(C)C(OC(C)=O)=C(C)C(C)=C2O1
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Synonyms
(±)-Vitamin E acetate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (211.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (5.29 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (5.29 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocole
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Protocol for Fluorescence In Situ Hybridization (FISH)
Fluorescence in situ hybridization detects specific DNA or RNA sequences inside fixed cells or tissue sections by hybridizing fluorescently labeled nucleic-acid probes to complementary target sequences, allowing the target’s copy number, chromosomal position, spatial distribution, or transcript abundance to be visualized microscopically. DNA-FISH detects genomic loci, chromosomal gains/losses, amplifications, deletions, and rearrangements, while RNA-FISH detects RNA molecules or transcript localization; in cancer cells, mouse tumors, neurons, organoids, macrophages, or drug-screening samples, the readout is fluorescent puncta, fusion/split signals, or localized RNA signal interpreted relative to validated controls.
Pureté et documentation
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Fiche technique (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1153 mL | 10.5766 mL | 21.1533 mL | 52.8832 mL |
| 5 mM | 0.4231 mL | 2.1153 mL | 4.2307 mL | 10.5766 mL | |
| 10 mM | 0.2115 mL | 1.0577 mL | 2.1153 mL | 5.2883 mL | |
| 15 mM | 0.1410 mL | 0.7051 mL | 1.4102 mL | 3.5255 mL | |
| 20 mM | 0.1058 mL | 0.5288 mL | 1.0577 mL | 2.6442 mL | |
| 25 mM | 0.0846 mL | 0.4231 mL | 0.8461 mL | 2.1153 mL | |
| 30 mM | 0.0705 mL | 0.3526 mL | 0.7051 mL | 1.7628 mL | |
| 40 mM | 0.0529 mL | 0.2644 mL | 0.5288 mL | 1.3221 mL | |
| 50 mM | 0.0423 mL | 0.2115 mL | 0.4231 mL | 1.0577 mL | |
| 60 mM | 0.0353 mL | 0.1763 mL | 0.3526 mL | 0.8814 mL | |
| 80 mM | 0.0264 mL | 0.1322 mL | 0.2644 mL | 0.6610 mL | |
| 100 mM | 0.0212 mL | 0.1058 mL | 0.2115 mL | 0.5288 mL |
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