IL-15 Protein, Rhesus macaque (HEK293, His)

The IL-15 Protein, a cytokine, plays a pivotal role in orchestrating inflammatory and protective immune responses against microbial invaders and parasites by modulating immune cells within both the innate and adaptive immune systems. Its influence extends to stimulating the proliferation of natural killer cells, T-cells, and B-cells, while also promoting the secretion of various cytokines. IL-15 exerts its effects in monocytes by inducing the production of IL8 and monocyte chemotactic protein 1/CCL2, attracting neutrophils and monocytes to infection sites. Notably, IL-15 differs from most cytokines in that it is expressed in association with its high-affinity receptor IL15RA on the surface of IL15-producing cells. This unique expression pattern allows IL-15 to deliver signals to target cells expressing IL2RB and IL2RG receptor subunits. Upon binding to its receptor, IL-15 triggers the phosphorylation of JAK1 and JAK3, recruiting and subsequently phosphorylating signal transducer and activator of transcription-3/STAT3 and STAT5. Additionally, in mast cells, IL-15 induces rapid tyrosine phosphorylation of STAT6, exerting control over mast cell survival and the release of cytokines such as IL4.