IRF9 Protein, Mouse
IRF9 Protein, Mouse is the recombinant mouse-derived IRF9 protein, expressed by E. coli, with tag free tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
IRF9 Protein, Mouse is the recombinant mouse-derived IRF9 protein, expressed by E. coli, with tag free tag.
IRF9 is a transcription factor that plays an essential role in anti-viral immunity. It mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Upon binding of type I IFNs to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G then associates with the phosphorylated STAT1:STAT2 dimer to form the ISGF3 transcription factor complex, which translocates into the nucleus. ISGF3 binds to the interferon-stimulated response element (ISRE) to activate transcription of interferon-stimulated genes, thereby inducing an antiviral state in the cell.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag Tag Free
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Accession
Q61179 (M1-H399)
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Gene ID16391
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Protein Length
Full Length
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Synonyms
IRF9; Interferon-Stimulated Transcription Factor 3, Gamma (48kD); Prev. ISGF3G; ISGF-3 Gamma; IFN-Alpha-Responsive Transcription Factor Subunit; IRF-9; Transcriptional Regulator ISGF3 Subunit Gamma; ISGF3; Interferon-Stimulated Gene Factor 3 Gamma; P48; I
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AA Sequence
MASGKVRCTRKLRSWIVEQVESGHFPGVCWDDAAKTMFRIPWKHAGKQDFREDQDAAIFKAWALFKEKHKDGDIGHPAVWKTRLRCALNKSSEFEEVPERGRMDVAEPYKVYRILPAGTLPNQPRNQKSPCKRSISCVSPEREENMENGRTNGVVNHSDSGSNIGGGGNGSNRSDSNSNCNSELEEGAGTTEATIREDPVFLEHQLPLNSDYSLLLTFIYGGRVVGKTQVHSLDCRLVAERSDSESSMEQVEFPKPDPLEPTQHLLNQLDRGVLVASNSRGLFVQRLCPIPISWNAPEAPPGPGPHLLPSNKCVELFKTTYFCRDLAQYFQGQGPPPKFQATLHFWEESPGSSHSQENLITVQMEQAFARHLLEKIPEEEKAALFLLQHTEQSPSALGH
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Predicted Molecular Mass
44.7 kDa
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Purity
≥ 80%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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