SIRT2 Protein, Human (GST)
SIRT2 Protein, Human (GST) is the recombinant human-derived SIRT2, expressed by E. coli , with GST labeled tag. ,
- Species: Human
- Source: E. coli
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
SIRT2 Protein, Human (GST) is the recombinant human-derived SIRT2, expressed by E. coli , with GST labeled tag. ,
Background
SIRT2 is an NAD-dependent protein deacetylase that targets histones (e.g., H4K16ac, H3K56ac), α-tubulin (e.g., Lys-40), and key transcription factors (e.g., FOXO1, FOXO3, HIF1A, RELA, p53/TP53). It regulates diverse processes including cell cycle control (e.g., G2/M transition, APC/C activation), genomic stability, microtubule dynamics, metabolic pathways (e.g., PPP, gluconeogenesis), autophagy, and epigenetic modifications (e.g., H4K20me1 deposition). During bacterial infection (e.g., Listeria monocytogenes) or oxidative stress, SIRT2 modulates transcriptional activity and stress responses via deacetylation. It also exhibits demyristoylation (e.g., ARF6) and depalmitoylation (e.g., KRAS) activities, influencing membrane localization. by similar: SIRT2 promotes FOXO3 ubiquitination and degradation through deacetylation.
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag GST
-
Accession
Q8IXJ6-1 (M1-Q389)
-
Gene ID22933
-
Protein Length
Full Length of Isoform-1
-
Synonyms
SIRT2; SIR2L2; Prev. SIR2L; Sirtuin (Silent Mating Type Information Regulation 2, S.Cerevisiae, Homolog) 2; NAD-Dependent Protein Defatty-Acylase Sirtuin-2; NAD-Dependent Deacetylase Sirtuin-2; NAD-Dependent Protein Deacetylase Sirtuin-2; Silent Informati
-
AA Sequence
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
-
Molecular Weight
Approximately 64 kDa, based on SDS-PAGE under reducing conditions.
-
Purity
≥ 85%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
