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Cat. No.: HY-103390

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Ro26-4550 TFA

Ro26-4550 TFA is a low micromolar antagonist of IL-2/IL-2Rα binding with an IC₅₀ value of 3 μM.

For research use only. We do not sell to patients.

CAS No.: 1217448-66-2
Formula: C₂₈H₃₁F₃N₄O₅
Molecular Weight:560.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Ro26-4550 TFA Chemical Structure

CAS No.: 1217448-66-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Ro26-4550 TFA is a low micromolar antagonist of IL-2/IL-2Rα binding with an IC₅₀ value of 3 μM^[1].

All Interleukin Related Isoforms :

Chemical Information

CAS No. 1217448-66-2
Molecular Weight 560.56
Formula C₂₈H₃₁F₃N₄O₅
SMILES

O=C(OC)[C@H](CC1=CC=C(C#CC2=CC=CC=C2)C=C1)NC(C[C@@H]3CN(C(N)=N)CCC3)=O.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Braisted AC, et al. Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J Am Chem Soc. 2003 Apr 2;125(13):3714-5. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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