RORγ-IN-2
RORγ-IN-2 (Compound 22) is a RORγ inhibitor, with a Ki of 16.6 nM for hRORγ. RORγ-IN-2 can be used for the research of IL-17-dependent autoimmune diseases.
For research use only. We do not sell to patients.
- CAS No.: 2088333-58-6
- Formula: C28H32F3N5O4S2
- Molecular Weight:623.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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RORγ 16.6 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PBMC | IC50 |
20 nM
Compound: 25
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Inhibition of IL-17A secretion in human PBMC cells
Inhibition of IL-17A secretion in human PBMC cells
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[PMID: 30010338] |
| PBMC | IC50 |
22 nM
Compound: 22
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Inhibition of IL-17A secretion in antiCD3/IL-23 stimulated human PBMC cells measured after 48 hrs by ELISA
Inhibition of IL-17A secretion in antiCD3/IL-23 stimulated human PBMC cells measured after 48 hrs by ELISA
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[PMID: 33852312] |
Chemical Information
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CAS No. 2088333-58-6
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Molecular Weight 623.71
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Formula C28H32F3N5O4S2
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SMILES
CCS(C(C=N1)=CC=C1CNC(C2=CC3=C(C4(O[C@H](C3)C)CCN(CC4)[C@@H](C5=CN=C(C(F)(F)F)N=C5)C)S2)=O)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RORγ-IN-2 Related Classifications
HY-W545294 Related Classifications
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