2. MAPK/ERK Pathway
  3. Ribosomal S6 Kinase (RSK)
  4. S6K1-IN-DG2

S6K1-IN-DG2 (Compound 66) is a p70S6K inhibitor (IC50: < 100 nM).

For research use only. We do not sell to patients.

S6K1-IN-DG2 Chemical Structure

S6K1-IN-DG2 Chemical Structure

CAS No. : 871340-88-4

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5 mg USD 110 In-stock
10 mg USD 170 In-stock
25 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

S6K1-IN-DG2 Related Antibodies

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Description

S6K1-IN-DG2 (Compound 66) is a p70S6K inhibitor (IC50: < 100 nM)[1].

Molecular Weight

389.25

Formula

C16H17BrN6O
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC1=NNC2=NC=NC(N3CCN(CC3)C4=C(OC)C=CC=C4)=C12
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (128.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5690 mL 12.8452 mL 25.6904 mL
5 mM 0.5138 mL 2.5690 mL 5.1381 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5690 mL 12.8452 mL 25.6904 mL 64.2261 mL
5 mM 0.5138 mL 2.5690 mL 5.1381 mL 12.8452 mL
10 mM 0.2569 mL 1.2845 mL 2.5690 mL 6.4226 mL
15 mM 0.1713 mL 0.8563 mL 1.7127 mL 4.2817 mL
20 mM 0.1285 mL 0.6423 mL 1.2845 mL 3.2113 mL
25 mM 0.1028 mL 0.5138 mL 1.0276 mL 2.5690 mL
30 mM 0.0856 mL 0.4282 mL 0.8563 mL 2.1409 mL
40 mM 0.0642 mL 0.3211 mL 0.6423 mL 1.6057 mL
50 mM 0.0514 mL 0.2569 mL 0.5138 mL 1.2845 mL
60 mM 0.0428 mL 0.2141 mL 0.4282 mL 1.0704 mL
80 mM 0.0321 mL 0.1606 mL 0.3211 mL 0.8028 mL
100 mM 0.0257 mL 0.1285 mL 0.2569 mL 0.6423 mL
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S6K1-IN-DG2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S6K1-IN-DG2871340-88-4Ribosomal S6 Kinase (RSK)S6Kp70S6Kkinaseproliferationdifferentiationprogrammed cell deathInhibitorinhibitorinhibit

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