Scutebarbatine X
Scutebarbatine X (Compound 2) is a neo-clerodane diterpenoids isolated from Scutellaria barbatae (Labiatae) and has anti-inflammatory properties.
For research use only. We do not sell to patients.
- CAS No.: 1312716-26-9
- Formula: C34H38N2O10
- Molecular Weight:634.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Scutebarbatine X significantly reduces the production of NO by LPS-stimulated BV2 cells in a dose-dependent manner, with an IC50 value of 27.4 μM[1].
Scutebarbatine X (15, 30 μM;1 h) dose-dependently reduces the expression of iNOS in BV2 cells[1].
Scutebarbatine X (7.5, 15, 30 μM; 24 h) does not reduce the viability of BV2 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1312716-26-9
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Molecular Weight 634.67
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Formula C34H38N2O10
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SMILES
O=C(C1=CC=CN=C1)O[C@H]2[C@H](OC(C3=CN=CC=C3)=O)[C@](C)(O)[C@](C)([C@@H](OC(C)=O)CC4=C(O)C(OC4)=O)[C@@]5([H])CCC=C(C)[C@]25C
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Scutebarbatine X Related Classifications
HY-N1263 Related Classifications
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