TEF - TEF transcription factor, PAR bZIP family member Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7008

About TEF

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,367,455-41,399,326 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 21.5), ovary (RPKM 19.9) and 24 other tissues.

Summary

This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult Animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with Other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

TEF Products (2)

mRNA Protein Name
NM_001145398.3 NP_001138870.1 thyrotroph embryonic factor isoform 2
NM_003216.4 NP_003207.1 thyrotroph embryonic factor isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEF Protein Structure

bZIP_2

bZIP_2: Basic region leucine zipper (232 - 285)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

thyrotroph embryonic factor

  • TEF, PAR bZIP transcription factor

TEF Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TEF Q10587 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
TEF Q10587 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
TEF Q10587 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
TEF Q10587 MRPL28 Homo sapiens Q13084
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tinea Manuum

  • Tinea Manus

  • Dermatophytosis Of Hand
Refractive Amblyopia

  • Ametropic Amblyopia
Tinea Unguium

  • Dermatophytosis Of Nail

  • Onychomycosis Due To Dermatophyte

  • Cellulitis And Abscess

  • Cellulitis And Abscess Of Buttock

  • Cellulitis And Abscess Of Face

  • Cellulitis And Abscess Of Finger

  • Cellulitis And Abscess Of Finger And Toe

  • Cellulitis And Abscess Of Gluteal Region

  • Cellulitis And Abscess Of Trunk

  • Cellulitis And Abscess Of Upper Arm And Forearm

  • Dermatophytic Onychia

  • Dermatophytic Onychomycosis

  • Onychomycosis

  • Ringworm Of Nails

  • Tinea Of Nail
Thyroid Hormone Resistance, Selective Pituitary

  • PRTH

  • Selective Pituitary Thyroid Hormone Resistance

  • Selective Pituitary Resistance To Thyroid Hormone

  • Familial Hyperthyroidism Due To Inappropriate Thyrotropin Secretion

  • Hyperthyroidism, Familial, Due To Inappropriate Thyrotropin Secretion

  • Pituitary Resistance To Thyroid Hormone
Tinea Cruris

  • Dermatophytosis Of Groin & Perianal Area

  • Dermatophytosis Of Groin And Perianal Area

  • Dhobie Itch

  • Tinea Of Perianal Region
Advanced Sleep Phase Syndrome

  • Fasps

  • Familial Advanced Sleep-Phase Syndrome

  • Advanced Sleep Phase Syndrome, Familial

  • Familial Advanced Sleep Phase Syndrome

  • Sleep Phase Syndrome, Advanced, Familial

  • Advanced Sleep-Phase Syndrome, Familial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159647 PLX-4545 96.76% Unkown
HY-N19180 Hancockiamide C / Unkown
HY-RS14353 TEF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-150033 Sorgoleone Inhibitor / Unkown
HY-RS19869 Tef Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26368 Tef Rat Pre-designed siRNA Set A Pre-designed Set / Unkown