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  3. Drug Derivative
  4. Hancockiamide C

Hancockiamide C is a phenylacetic piperazine natural products found in Aspergillus hancockii. Hancockiamide C is synthesized via the hkm biosynthetic gene cluster, involving NRPS Hkm11 and the acetyltransferase Hkm3. Hancockiamide C inhibits seed germination of Arabidopsis thaliana (MIC = 6.3 μg/mL), but shows no activity against Eragrostis tef seeds.

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Hancockiamide C

Hancockiamide C Chemical Structure

CAS No. : 2758265-36-8

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Hancockiamide C Related Antibodies

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Description

Hancockiamide C is a phenylacetic piperazine natural products found in Aspergillus hancockii. Hancockiamide C is synthesized via the hkm biosynthetic gene cluster, involving NRPS Hkm11 and the acetyltransferase Hkm3. Hancockiamide C inhibits seed germination of Arabidopsis thaliana (MIC = 6.3 μg/mL), but shows no activity against Eragrostis tef seeds[1].

In Vitro

Hancockiamide C potently inhibits Arabidopsis thaliana seed germination with an MIC of 6.3 μg/mL but does not affect Eragrostis tef seed germination[1].
Hancockiamide C is biosynthesized via the hkm gene cluster, and heterologous expression of the full hkm gene cluster in A. nidulans results in its production, while the cytochrome P450 enzyme Hkm5 catalyzes the conversion of hancockiamide B to hancockiamide C in A. nidulans[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hancockiamide C Related Antibodies
Molecular Weight

512.61

Formula

C31H32N2O5
CAS No.
SMILES

C([C@@H]1N(C(/C=C/C2=CC=CC=C2)=O)C[C@H](CC3=CC=CC=C3)N(C(C)=O)C1)C=4C=C5C(=C(OC)C4)OCO5
Structure Classification
Initial Source

Aspergillus hancockii
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Hancockiamide C Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hancockiamide C2758265-36-8Drug DerivativeDrug derivativeA. nidulansAspergillus hancockiiEragrostis tefArabidopsis thalianacytochrome P450 Hkm5hancockiamide Bhkm gene clusterInhibitorinhibitorinhibit

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