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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3472 Results for "
Prothrombin complex concentrate
" in MedChemExpress (MCE) Product Catalog:
Products (3472)
3472 Results for "Prothrombin complex concentrate" in MCE Product Catalog:
Cat. No.: HY-L211
86 compounds
Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases.
MCE has included 86 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.
Cat. No.: HY-L176
7,362 compounds
The occurrence of diseases is often associated with multiple targets and pathways, and the factors of disease formation are complex and diverse, so the development of more powerful drugs is needed. According to statistics, 21% of the FDA-approved drugs in 2015-2017 were multi-target compounds. Multi-target compounds refer to a drug targeting multiple disease-related targets or multiple subtypes of a target. Multi-target compounds can be applied to drug screening or targeted ligand design. Because the targets of such compounds are diverse and clear, they have the characteristics of saving time and drug cost during the mechanism research of new drug research and development. In addition, due to the diversity of drug targets, multiple strategies can be applied to pharmacological studies.
MCE supplies a unique collection of 7,362 multi-target compounds that targets two or more different targets or different subtypes of the same target. MCE Multi-Target Compound Library can be used for target protein ligand screening or drug development.
Cat. No.: HY-L175
178 compounds
Inflammasomes are classic pattern recognition receptors for natural immune responses. Inflammasomes are polymeric protein complexes that regulate inflammatory responses and pyrolytic cell death, thereby exerting the host's defense against microorganisms. Inflammasomes sensors are associated with adapter proteins, activating inflammatory caspase-1, releasing inflammatory cytokines and inducing cell death, endowing the host with defense against pathogens. NLRP1, NLRP3, NLRC4, AIM2, and pyrin are considered typical inflammasomes because they convert cysteine asparaginase-1 into catalytically active capsaicin-1. In addition to infectious diseases, the importance of inflammasomes is also related to various clinical diseases, such as autoimmune diseases, neurodegeneration and metabolic disorders, and the development of cancer. Therefore, it is necessary to strictly regulate the activation and function of inflammasomes to avoid accidental host tissue damage while inducing pathogens to kill the inflammatory response.
MCE designs a unique collection of 178 inflammasomes related compounds. It is a good tool to be used for research on Inflammation, cancer and other diseases.
Cat. No.: HY-145514R
CAS No.: 2624313-15-9
Target:
Research Areas:
dTAGV-1 TFA (Standard) is the analytical standard of dTAGV-1 TFA (HY-145514). This product is intended for research and analytical applications. dTAGV-1 TFA is a selective FKBP12 F36V PORTAC degrader. dTAGV-1 TFA induces rapid degradation of FKBP12 F36V-tagged oncogenic fusion proteins, triggering collapse of downstream cellular signaling pathways, reduced proliferative capacity of cancer cells, and decreased levels of target proteins. dTAGV-1 TFA is applicable to functional validation studies of cancer and undegradable oncoproteins .
Target:
Research Areas:
PROTAC_ERRα is a potent and selective ERRα PROTAC degrader (DC50: ~100 nM in MCF-7 cells). PROTAC_ERRα recruits the VHL E3 ubiquitin ligase to ERRα, inducing ERRα ubiquitination and proteasomal degradation in a VHL-dependent manner. PROTAC_ERRα can be used in breast cancer-related research .
Research Areas:
VHL-IN-1 (Compound 30) is an E3 ligase VHL inhibitor with a Kd value of 37 nM. VHL-IN-1 blocks VHL-mediated ubiquitination and degradation of HIF-1α. VHL-IN-1 stabilizes the protein levels of HIF-1α and hydroxylated HIF-1α, and induces the transcriptional activity of HIF-1α. VHL-IN-1 can be used for PROTAC development. VHL-IN-1 is applicable for cancer research .
Cat. No.: HY-186130
CAS No.: 3110929-05-7
Target:
Research Areas:
CAST-calpain-2 stabilizer-1 is a blood-brain barrier permeable stabilizer of CAST-calpain-2 interaction. CAST-calpain-2 stabilizer-1 shows no activity against GSK3. CAST-calpain-2 stabilizer-1 can be used in the research of Huntington's disease and tauopathies .
Cat. No.: HY-W016814A
CAS No.: 499-12-7
Synonyms: NSC 7616
Aconitic acid (NSC 7616) is an Antibacterial agent. Aconitic acid exerts dose-dependent inhibitory effects on Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus in vitro. Aconitic acid can be used in studies related to bacterial infections .
Cat. No.: HY-W041994
CAS No.: 80307-12-6
Research Areas:
GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins .
Cat. No.: HY-W197533
CAS No.: 65474-79-5
Target:
Research Areas:
3-Hydroxymethyl-β-carboline is a Benzodiazepine antagonist with a Ki value of ~1470 nM. 3-Hydroxymethyl-β-carboline reverses Flurazepam-induced sleep, cerebrovascular and cerebral metabolic inhibition, and also partially reverses Flurazepam-induced decreases in blood pressure and heart rate. 3-Hydroxymethyl-β-carboline disrupts the anticonvulsant and anxiolytic effects of Diazepam in male mice. 3-Hydroxymethyl-β-carboline has no effect on sodium-dependent high-affinity choline uptake in rat cortical or hippocampal synaptosomes .
Cat. No.: HY-W450898
CAS No.: 13965-31-6
Target:
Research Areas:
(2,2'-Bipyridine) dichloroplatinum (II) is a Pt (II) analog of Cisplatin (HY-17394) that induces cytotoxic activity in lung cancer, prostate cancer and melanoma cells. (2,2'-Bipyridine) dichloroplatinum (II) can be used in research related to lung cancer, prostate cancer and melanoma .
Cat. No.: HY-Y0131
CAS No.: 19847-12-2
Cat. No.: HY-P7879
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD3D; CD3d Molecule, Delta (CD3-TCR complex); Prev. T3D; CD3 Antigen, Delta Subunit; T-Cell Surface Glycoprotein CD3 Delta Chain; OKT3, Delta Chain; T-Cell Receptor T3 Delta Chain; CD3d Molecule; CD3-DELTA; CD3d Antigen; CD3DELTA; IMD19; CD3d Antigen, Del
Species:
Human
Source:
HEK293
Cat. No.: HY-P70091
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD3D; CD3d Molecule, Delta (CD3-TCR complex); Prev. T3D; CD3 Antigen, Delta Subunit; T-Cell Surface Glycoprotein CD3 Delta Chain; OKT3, Delta Chain; T-Cell Receptor T3 Delta Chain; CD3d Molecule; CD3-DELTA; CD3d Antigen; CD3DELTA; IMD19; CD3d Antigen, Del
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P71539
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LY6E; Thymic Shared Antigen 1; Lymphocyte Antigen 6 Family Member E; Lymphocyte Antigen 6E; TSA-1; Stem Cell Antigen 2; RIG-E; Ly-6E; SCA-2; RIGE; Lymphocyte Antigen 6 complex, Locus E; SCA2; Retinoic Acid-Induced Gene E Protein; TSA1; Retinoic Acid Induc
Species:
Human
Source:
E. coli
Cat. No.: HY-P71830
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LY6E; Thymic Shared Antigen 1; Lymphocyte Antigen 6 Family Member E; Lymphocyte Antigen 6E; TSA-1; Stem Cell Antigen 2; RIG-E; Ly-6E; SCA-2; RIGE; Lymphocyte Antigen 6 complex, Locus E; SCA2; Retinoic Acid-Induced Gene E Protein; TSA1; Retinoic Acid Induc
Species:
Mouse
Source:
P. pastoris
Cat. No.: HY-P72728
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD3D; CD3d Molecule, Delta (CD3-TCR complex); Prev. T3D; CD3 Antigen, Delta Subunit; T-Cell Surface Glycoprotein CD3 Delta Chain; OKT3, Delta Chain; T-Cell Receptor T3 Delta Chain; CD3d Molecule; CD3-DELTA; CD3d Antigen; CD3DELTA; IMD19; CD3d Antigen, Del
Species:
Cynomolgus
Source:
HEK293
Cat. No.: HY-P75654
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD3D; CD3d Molecule, Delta (CD3-TCR complex); Prev. T3D; CD3 Antigen, Delta Subunit; T-Cell Surface Glycoprotein CD3 Delta Chain; OKT3, Delta Chain; T-Cell Receptor T3 Delta Chain; CD3d Molecule; CD3-DELTA; CD3d Antigen; CD3DELTA; IMD19; CD3d Antigen, Del
Species:
Mouse
Source:
HEK293
Cat. No.: HY-P76803
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD3D; CD3d Molecule, Delta (CD3-TCR complex); Prev. T3D; CD3 Antigen, Delta Subunit; T-Cell Surface Glycoprotein CD3 Delta Chain; OKT3, Delta Chain; T-Cell Receptor T3 Delta Chain; CD3d Molecule; CD3-DELTA; CD3d Antigen; CD3DELTA; IMD19; CD3d Antigen, Del
Species:
Canine
Source:
HEK293
Cat. No.: HY-P80389
Synonyms: CDK7_HUMAN; Cyclin-dependent kinase 7; EC:2.7.11.22; EC:2.7.11.23; CDK7; CAK; CAK1; CDKN7; MO15; STK1; 39 kDa protein kinase (p39 Mo15); CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
