2. Epigenetics
  3. Epigenetic Reader Domain
  4. PROTAC_ERRα

PROTAC_ERRα is a potent and selective ERRα degrader. PROTAC_ERRα induces proteasomal degradation and has capable of specifically degrading ERRα protein by >80%.

For research use only. We do not sell to patients.

PROTAC_ERRα Chemical Structure

PROTAC_ERRα Chemical Structure

CAS No. : 1801547-15-8

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PROTAC_ERRα Related Antibodies

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Description

PROTAC_ERRα is a potent and selective ERRα degrader. PROTAC_ERRα induces proteasomal degradation and has capable of specifically degrading ERRα protein by >80%[1].

In Vitro

PROTAC_ERRα (0-1000 nM; 8 hours; MCF7 cells) down-regulates ERRα protein levels in a dose-dependent fashion[1].
PROTAC_ERRα (100-500 nM; 4-24 hours; MCF7 cells) possesses good selectivity for ERRα target and decreases protein levels of ERRα downstream target genes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC_ERRα Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF7 cells
Concentration: 0, 10, 30, 100, 300 and 1000 nM
Incubation Time: 8 hours
Result: Decreased in ERRα level in a dose-dependent fashion and the maximal level of degradation (D50) is 86%.
In Vivo

PROTAC_ERRα (100 mg/kg; i.p.; every eight hours) degrades ERRα level in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 mice[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection ; every eight hours.
Result: Reduced ERRα levels in mouse heart and kidney and MDA-MB-231 tumors by approximately 44%, 44% and 39%, respectively.
Molecular Weight

949.03

Formula

C46H47F3N6O9S2
CAS No.
SMILES

O=C(/C(SC1=O)=C/C2=CC(OC)=C(C=C2)OC3=C(C=C(C=C3)C#N)C(F)(F)F)N1CCOCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C[C@H](C4)O)C(NCC5=CC=C(C6=C(N=CS6)C)C=C5)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC_ERRα Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC_ERRα1801547-15-8Epigenetic Reader DomainERRαproteasomaldegraderInhibitorinhibitorinhibit

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PROTAC_ERRα
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HY-147174
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