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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
193 Results for "
APP
" in MedChemExpress (MCE) Product Catalog:
Products (193)
193 Results for "APP" in MCE Product Catalog:
2
2 Cited Publications
Target:
Research Areas:
TD52 dihydrochloride, an Erlotinib (HY-50896) derivative, is an orally active, potent cancerous inhibitor of protein phosphatase 2A (CIP2A) inhibitor. TD52 dihydrochloride mediates the apoptotic effect in triple-negative breast cancer (TNBC) cells via regulating the CIP2A/PP2A/p-Akt signalling pathway. TD52 dihydrochloride indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter. TD52 dihydrochloride has less p-EGFR inhibition and has potent anti-cancer activity . TD52 (dihydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
1
1 Cited Publications
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N-Methylprotoporphyrin IX is a Ferrochelatase inhibitor with a Ki app value of 3 nM. N-methylprotoporphyrin IX dimethyl ester potently inhibits the synthesis of phycocyanin and chlorophyll a. N-Methylprotoporphyrin IX can be used for the research of haem deficiency-associated disorders .
1
1 Cited Publications
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CZC24832 is a highly selective and potent PI3Kγ inhibitor (IC50=27 nM) with apparent dissociation constants (Kd app) of 19 nM.
1
1 Cited Publications
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δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research .
1
1 Cited Publications
Cat. No.: HY-P704352
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: APP; PreA4; Prev. AD1; CVAP; Alzheimer Disease Amyloid A4 Protein Homolog; Beta-Amyloid Precursor Protein; Amyloid-Beta Precursor Protein; Testicular Tissue Protein Li 2; Amyloid Precursor Protein; Beta-Amyloid Peptide(1-40); Alpha-SAPP; Beta-Amyloid Pept
Species:
Human
Source:
HEK293
1
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Buntanetap ((+)-Phenserine) is a selective acetylcholinesterase inhibitor. Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease .
1
1 Cited Publications
Cat. No.: HY-19918A
Research Areas:
Anatabine dicitrate is a tobacco alkaloid that can cross the blood-brain barrier. Anatabine dicitrate is a potent α4β2 nAChR agonist. Anatabine dicitrate inhibits NF-κB activation lower amyloid-β (Aβ) production by preventing the β-cleavage of amyloid precursor protein (APP). Anatabine dicitrate has anti-inflammatory effects and has the potential for neurodegenerative disorders treatment .
1
1 Cited Publications
Cat. No.: HY-16009B
CAS No.: 865795-23-9
Synonyms: (+)-Phenserine L-Tartrate; ANVS401 L-Tartrate
Target:
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Buntanetap L-Tartrate (Phenserine L-Tartrate) is a selective AChE inhibitor (IC50 = 22.2 nM). Buntanetap is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap reduces the production of β-amyloid precursor protein by blocking its mRNA translation. Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer's disease and Parkinson's disease .
1
1 Cited Publications
Cat. No.: HY-P78682
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CTSB; Keratolytic Winter Erythema (Oudtshoorn Skin Disease); Cathepsin B; Epididymis Secretory Sperm Binding Protein; APP Secretase; Amyloid Precursor Protein Secretase; Cathepsin B1; Cysteine Protease; APPS; RECEUP; CPSB; KWE
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P5381
CAS No.: 329902-61-6
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
1
Cat. No.: HY-50883
CAS No.: 290315-45-6
Target:
Research Areas:
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
Cat. No.: HY-128464
CAS No.: 2672496-32-9
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LL320 is a selective NNMT inhibitor with a Ki,app of 6.8 nM. LL320 exhibits interactions with RNMT, DPH5, and SAHH .
Synonyms: Dimebolin dihydrochloride
Research Areas:
Latrepirdine dihydrochloride is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.
Cat. No.: HY-128585
CAS No.: 2438637-64-8
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GNE684 is a potent inhibitor of potent receptor interacting protein 1 (RIP1), with mean Ki app values of 21 nM, 189 nM and 691 nM for human mouse and rat RIP1, respectively .
Cat. No.: HY-P6365B
CAS No.: 452782-06-8
Synonyms: D-4F
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Cat. No.: HY-18292
CAS No.: 102212-26-0
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ARN2966 is a potent, orally active and cross the blood-brain barrier amyloid precursor protein (APP) translation modulator.
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Research Areas:
CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Ki app) of 330 nM .
Research Areas:
Latrepirdine is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.
Target:
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LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
