842964-18-5
Chemical Structure
δ-Secretase inhibitor 11
- CAS No.: 842964-18-5
- Formula:C10H12N4O2
- Molecular Weight:220.23
IUPAC Name: 7-morpholinobenzo[c][1,2,5]oxadiazol-4-amine
InChIKey: LWCSTSZSZFUHAT-UHFFFAOYSA-N
SMILES: NC1=CC=C(N2CCOCC2)C3=NON=C31
Biological Activity: δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research[1].
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δ-Secretase inhibitor 11 | 99.89% | δ-Secretase inhibitor 11 (compound 11) is an orally active, potent, BBB-penetrated, non-toxic, selective and specific δ-secretase inhibitor, with an IC50 of 0.7 μM. δ-Secretase inhibitor 11 interacts with both the active site and allosteric site of δ-secretase. δ-Secretase inhibitor 11 attenuates tau and APP (amyloid precursor protein) cleavage. δ-Secretase inhibitor 11 ameliorates synaptic dysfunction and cognitive impairments in tau P301S and 5XFAD transgenic mouse models. δ-Secretase inhibitor 11 can be used for Alzheimer's disease research. | ||||||||||||||||||||
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Keywords
