1. MAPK/ERK Pathway
  2. MAPKAPK2 (MK2)
  3. CMPD1

CMPD1 

Cat. No.: HY-108643 Purity: >99.0%
Handling Instructions

CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM.

For research use only. We do not sell to patients.

CMPD1 Chemical Structure

CMPD1 Chemical Structure

CAS No. : 41179-33-3

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10 mM * 1 mL in DMSO USD 286 Ask For Quote & Lead Time
5 mg USD 260 Ask For Quote & Lead Time

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Description

CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM[1][2].

IC50 & Target

Kiapp: 330 nM (MK2 phosphorylation)[2]

In Vitro

CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2[1].
CMPD1 induced mitotic arrest and apoptosis in U87 cells[1].
CMPD1 inhibits tubulin polymerisation in glioblastoma cells[3].

Molecular Weight

349.40

Formula

C₂₂H₂₀FNO₂

CAS No.

41179-33-3

SMILES

O=C(NC1=CC=C(O)C=C1)CCCC2=CC=C(C3=CC=CC=C3F)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

CMPD1CMPD 1CMPD-1MAPKAPK2 (MK2)Mitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2Inhibitorinhibitorinhibit

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