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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
CPI
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "CPI" in MCE Product Catalog:
Cat. No.: HY-15846A
CAS No.: 202591-23-9
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(Rac)-CPI-203 is a racemate of CPI-203 (HY-15846) (BET bromodomain inhibitor)
Cat. No.: HY-134899
CAS No.: 2390367-27-6
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CPI-1328 is an EZH2 inhibitor with a Ki value of 63 fM.
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(R,R)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity .
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(S,S)-CPI-1612 is the isomer of CPI-1612 (HY-136285), and can be used as an experimental control. CPI-1612 is a highly potent, orally active EP300/CBP histone acetyltransferase (HAT) inhibitor with an IC50 of 8.1 nM for EP300 HAT. CPI-1612 has an anticancer activity .
Cat. No.: HY-111085
CAS No.: 931078-17-0
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CPI-905 is a potent, selective, and cell-active EZH2 inhibitor .
Cat. No.: HY-120196
CAS No.: 1904649-00-8
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CPI703, a BRD inhibitor, binds with residues in domain1 of 5DBM complex .
Cat. No.: HY-161250
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Pomalidomide-NH-PEG6-amide-C2-CPI-1612 is a CBP/EP300 PROTAC degrader with a DC50 value of 1.3 μM. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 mediates the formation of a ternary complex between CRBN and the core of CBP, with an EC50 of 1.2 μM. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 inhibits cancer cell growth and exhibits cell line-specific degradation activity. Pomalidomide-NH-PEG6-amide-C2-CPI-1612 can be used in research related to multiple myeloma and leukemia .
(Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans .
Cat. No.: HY-159777
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CPI-203-PEG5-Alkyne is a conjugate of target protein ligase and linker. CPI-203-PEG5-Alkyne can be used for synthesis of PROTAC BRD4-DCAF1 degrader-1 (HY-169151) .
Cat. No.: HY-106154
CAS No.: 274912-87-7
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DTS-201 (CPI-0004) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer .
Cat. No.: HY-122081
CAS No.: 1904647-34-2
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CPI-644 is a selective EP300/CBP bromodomain inhibitor, with an IC50 of 0.18 µM against the CBP bromodomain. CPI-644 reduces the proportion of FOXP3 + cells and downregulates the expression of LAG-3, CTLA-4 and PD-1. CPI-644 can be used in cancer-related research .
Cat. No.: HY-100421R
CAS No.: 1628208-23-0
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CPI-455 (Standard) is the analytical standard of CPI-455 (HY-100421). This product is intended for research and analytical applications. CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents .
Cat. No.: HY-100482R
CAS No.: 1884712-47-3
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CPI-637 (Standard) is the analytical standard of CPI-637 (HY-100482). This product is intended for research and analytical applications. CPI-637 is a selective and potent CBP/EP300 bromodomain inhibitor with IC50 values of 0.03 μM, 0.051 μM and 11.0 μM for CBP, EP300 and BRD4 BD-1, respectively, and an EC50 of 0.3 μM for CBP .
Cat. No.: HY-121946
CAS No.: 35512-29-9
Synonyms: 4-(4-Chlorophenyl)imidazole
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4-CPI (4-(4-Chlorophenyl)imidazole) is a CYP2B4 inhibitor with an IC50 of 0.11 μM and a Kd of 0.043 μM. The Ks of 4-CPI for cytochrome P450eryF (S93C/C154S mutant) is 9.4 μM, with no allosteric cooperative effect of ligand binding . 4-CPI binds to CYP2B4 at a 1:1 ratio, which induces substantial conformational changes in the enzyme's active pocket to form a closed crystal conformation (PDB:1SUO). 4-CPI can be used to investigate the flexibility of P450 active pockets, protein-ligand binding thermodynamics, and the allosteric mechanisms of P450 .
Cat. No.: HY-101978R
CAS No.: 1202402-40-1
Synonyms: CPI-444 (Standard); V81444 (Standard)
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Ciforadenant (Standard) is the analytical standard of Ciforadenant (HY-101978). This product is intended for research and analytical applications. Ciforadenant (CPI-444) is a potent, orally active and selective adenosine A2A receptor (A2AR) antagonist, which induces antitumor responses .
Cat. No.: HY-150298R
CAS No.: 2226636-04-8
Synonyms: CPI-818 (Standard)
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Soquelitinib (Standard) is the analytical standard of Soquelitinib (HY-150298). This product is intended for research and analytical applications. Soquelitinib (CPI-818) is an orally active and highly selective covalent interleuKin-2-inducible Kinase (ITK) inhibitor. Soquelitinib is active in six different models of T cell-mediated inflammatory and immune disease, including acute and chronic asthma, pulmonary fibrosis, systemic sclerosis (scleroderma), psoriasis, and acute graft versus host disease with Th2 cytoKine product inhibition. Soquelitinib increases tumor infiltration of normal CD8 + cells that possess enhanced T effector function .
Cat. No.: HY-15453R
CAS No.: 95809-78-2
Synonyms: CPI-613 (Standard)
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Devimistat (Standard) is the analytical standard of Devimistat (HY-15453). This product is intended for research and analytical applications. Devimistat is a mitochondrial metabolism inhibitor. Devimistat is a lipoic acid antagonist that abrogates mitochondrial energy metabolism to induce apoptosis in various cancer cells .
Cat. No.: HY-175898
CAS No.: 3054145-02-4
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CBP/EP300 ligand-1 is a ligands for target protein for PROTAC. CBP/EP300 ligand-1 can be used to synthesize PROTAC Pomalidomide-NH-PEG6-amide-C2-CPI-1612 (HY-161250).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
