55 Results for "

Cys481

" in MedChemExpress (MCE) Product Catalog:
Products (55)

55 Results for "Cys481" in MCE Product Catalog:

Cat. No.: HY-P3099A
Target:  

Guanylate Cyclase

Research Areas:  

Cancer

Uroguanylin (human) (TFA) is a natural ligand for the Guanylyl Cyclase (GCC) receptor expressed in metastatic colorectal cancer tumors. Uroguanylin (human) (TFA) has anti-tumor actions in an animal model for human colon cancer .
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Cat. No.: HY-P5077A
Target:  

Guanylate Cyclase

Research Areas:  

Metabolic Disease

Guanylin (mouse, rat) TFA, a petide, is composed of 15 amino acids. Guanylin (mouse, rat) TFA is an activator of intestinal guanylate cyclase. Guanylin (mouse, rat) TFA can be used for the research of diarrhea .
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Cat. No.: HY-P5925A
Synonyms: SsTx Toxin TFA
Ssm Spooky Toxin TFA is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC50s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin TFA inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin TFA plays an essential role in the centipede’s circulatory system .
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Cat. No.: HY-P5807
Synonyms: β-Mammal toxin Cn2
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Cn2 toxin is aβ- toxoins. Cn2 toxin can bind to the voltage sensing domain of voltage gated sodium channels (Nav) .
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Cat. No.: HY-W757743
Synonyms: ACP-196-d3
Acalabrutinib-d3 (ACP-196-d3) is the deuterated form of Acalabrutinib (HY-17600). Acalabrutinib (ACP-196) is an orally active, irreversible, highly selective second-generation BTK inhibitor. Acalabrutinib covalently binds to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib shows strong targeting and efficacy in mouse models of chronic lymphocytic leukemia (CLL).
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Cat. No.: HY-P5300A
Target:  

Inhibitory Antibodies

Research Areas:  

Others

YNPCVMYL (Thioester: Cys4-Leu8) TFA is a polypeptide chain of the YNPCVMYL sequence. The link between the fourth and eighth amino acids in the sequence has the properties of a thioester, which is formed between cysteine (Cys4) and leucine (Leu8).
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Cat. No.: HY-P3912
CAS No.: 147396-10-9
Target:  

COX Interleukin Related

Research Areas:  

Infection

Endotoxin inhibitor a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor inhibits the febrile response to LPS with very low toxicity and lethality .
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Cat. No.: HY-12554B
CAS No.: 914453-96-6
Terlipressin acetate is a vasopressin analogue with potent vasoactive properties. Terlipressin acetate is a highly selective vasopressin V1 receptor agonist that reduces the splanchnic blood flow and portal pressure and controls acute variceal bleeding. Terlipressin acetate exerts anti-inflammatory and anti-oxidative effects. Terlipressin acetate has the potential for hepatorenal syndrome and norepinephrine-resistant septic shock research .
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Cat. No.: HY-P1766
CAS No.: 163648-32-6
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

Adrenomedullin (11-50), rat is the C-terminal fragment (11-50) of rat adrenomedullin. Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors .
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Cat. No.: HY-P5816
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

BmK-M1 is a scorpion toxin, and is composed of 64 amino acids cross-linked by four disulfide bridges. BmK-M1 inhibits Na + channel and can be considered both as a cardiotoxin and a neurotoxin .
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Cat. No.: HY-P5925
Synonyms: SsTx Toxin
Ssm Spooky Toxin is found in Scolopendra mutilans that potently inhibits KCNQ (voltage-gated potassium channel family 7) channels, with IC50s of 2.8 μM, 5.26 μM and 0.1-0.3 M for Kv7.4, Kv1.3, and Shal channel, respectivily. Ssm Spooky Toxin inhibits cytokine generation by specifically acting on the KV1.3 channel in T cells. Ssm Spooky Toxin plays an essential role in the centipede’s circulatory system .
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Cat. No.: HY-P1219
CAS No.: 925463-91-8
Synonyms: β-TRTX-Cj1α
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Jingzhaotoxin-III is a potent and selective blocker of Nav1.5 channels, with an IC50 of 348 nM, and shows no effect on other sodium channel isoforms. Jingzhaotoxin-III can selectively inhibit the activation of cardiac sodium channel but not neuronal subtypes, and hopefully represents an important ligand for discriminating cardiac VGSC subtype .
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Cat. No.: HY-16525
CAS No.: 701909-57-1
XEN-2174 is a noradrenaline transporter (NET) inhibitor. XEN-2174 inhibits the reuptake of noradrenaline through non-competitive inhibition, increasing the concentration of noradrenaline in the synaptic cleft, thereby activating α2-adrenergic receptor at the spinal level and exerting analgesic effects. XEN-2174 exhibits long-lasting analgesic effects in models of neuropathic pain and postoperative pain in rats. XEN-2174 can be used in pain research .
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Cat. No.: HY-131374
CAS No.: 368874-31-1
Target:  

CXCR

Research Areas:  

Cancer

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity .
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Cat. No.: HY-17600A
CAS No.: 2242394-65-4
Synonyms: Calquence maleate; ACP-196 maleate
Target:  

Btk

Research Areas:  

Cancer

Acalabrutinib (Calquence) maleate is an orally active, irreversible, and highly selective second-generation BTK inhibitor. Acalabrutinib binds covalently to Cys481 in the ATP-binding pocket of BTK. Acalabrutinib maleate demonstrates potent on-target effects and efficacy in mouse models of chronic lymphocytic leukemia (CLL). Acalabrutinib maleate can be used for CLL research . Acalabrutinib maleate is a click chemistry reagent, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cat. No.: HY-P1600
CAS No.: 58100-03-1
Target:  

Inhibitory Antibodies

Research Areas:  

Others

Tyr-Somatostatin-14 is a customized peptide that adds a Tyrosine amino acid to Somatostatin-14.
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Cat. No.: HY-P10260
CAS No.: 114547-28-3
Synonyms: pBNP-26
Research Areas:  

Others

BNP (7-32), porcine (pBNP-26) is an atrial natriuretic peptide, which utilized in radioimmunoassay .
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Cat. No.: HY-P4898A
Target:  

Sodium Channel

Research Areas:  

Cardiovascular Disease

Anthopleurin-A TFA is a soidum channel toxin. Anthopleurin-A TFA is selective for cardiac channels and has cardiotonic effect. Anthopleurin-A TFA can be isolated from the sea anemone .
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Cat. No.: HY-P10469
Target:  

NF-κB

Research Areas:  

Inflammation/Immunology Cancer

NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc .
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Cat. No.: HY-P10684
CAS No.: 125139-68-6
Target:  

Bacterial

Research Areas:  

Infection

Polyphemusin II is an antimicrobial peptide which can be isolated from Limulus polyphemus hemocytes. Polyphemusin II exhibits antimicrobial activities against various Gram (+)/(-) bacteria and fungi .
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