TN14003
TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 368874-31-1
- Formula: C90H141N33O18S2
- Molecular Weight:2037.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | CC50 |
410 μM
Compound: TN-14003
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Cytotoxicity against MDA-MB-231 cells
Cytotoxicity against MDA-MB-231 cells
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[PMID: 17958344] |
| MDA-MB-231 | IC50 |
0.6 nM
Compound: TN-14003
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Inhibition of CXCR4 in MDA-MB-231 cells
Inhibition of CXCR4 in MDA-MB-231 cells
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[PMID: 17958344] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 368874-31-1
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Molecular Weight 2037.42
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Formula C90H141N33O18S2
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Sequence
Arg-Arg-{Ala-(2-Naph)}-Cys-Tyr-{Cit}-Lys-Lys-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys13)
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Sequence Shortening
RR-{Ala-(2-Naph)}CY-{Cit}-KKPYR-{Cit}-CR-NH2 (Disulfide bridge: Cys4-Cys13)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Subcutaneous Cell-Line-Derived Xenograft
Subcutaneous cell-line-derived xenograft (CDX) models are established by implanting cultured human cancer cell lines into immunodeficient mice, where the injected cells form localized tumors that can be monitored in vivo as a measure of tumorigenic potential, growth kinetics, and treatment response. These models are widely used in oncology research because they allow reproducible tumor formation and enable comparative assessment of tumor growth between different cell lines or genetic manipulations in a controlled in vivo microenvironment. Subcutaneous implantation of cancer cells in immunodeficient mice is a standard approach for evaluating tumor growth behavior and therapeutic response across multiple cancer types, including prostate, esophageal, pancreatic, and colon cancer models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TN14003 Related Classifications
HY-131374 Related Classifications
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