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Cat. No.: HY-131374

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TN14003

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 368874-31-1
Formula: C₉₀H₁₄₁N₃₃O₁₈S₂
Molecular Weight:2037.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TN14003 Chemical Structure

CAS No.: 368874-31-1

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Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity^[1].

All CXCR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	CC₅₀	410 μM Compound: TN-14003	Cytotoxicity against MDA-MB-231 cells Cytotoxicity against MDA-MB-231 cells	[PMID: 17958344]
MDA-MB-231	IC₅₀	0.6 nM Compound: TN-14003	Inhibition of CXCR4 in MDA-MB-231 cells Inhibition of CXCR4 in MDA-MB-231 cells	[PMID: 17958344]

In Vivo

TN14003 (7.5 mg/kg, intraperitoneal injection, 5 days per week) inhibits HER2 tumor growth by reducingangiogenesis and myofibroblast content^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 368874-31-1
Molecular Weight 2037.42
Formula C₉₀H₁₄₁N₃₃O₁₈S₂
Sequence

Arg-Arg-{Ala-(2-Naph)}-Cys-Tyr-{Cit}-Lys-Lys-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys13)
Sequence Shortening

RR-{Ala-(2-Naph)}CY-{Cit}-KKPYR-{Cit}-CR-NH2 (Disulfide bridge: Cys4-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lefort S, et al. CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients. Oncogene. 2017 Mar 2;36(9):1211-1222. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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