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Cat. No.: HY-P3912

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Endotoxin inhibitor

Endotoxin inhibitor a synthetic peptide that binds lipid A with high affinity, thereby detoxifying LPS (HY-D1056) and preventing LPS-induced cytokine release in vivo. Endotoxin inhibitor inhibits the febrile response to LPS with very low toxicity and lethality.

For research use only. We do not sell to patients.

CAS No.: 147396-10-9
Formula: C₅₅H₉₇N₁₅O₁₂S₂
Molecular Weight:1224.58

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Endotoxin inhibitor Chemical Structure

CAS No.: 147396-10-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All COX Isoforms :

All Interleukin Related Isoforms :

In Vivo

Endotoxin inhibitor (i.p., 0.5 mg/kg) significantly attenuates heat exposure-induced increases in mRNA for IL-1β, COX-2, IκB-β, and LPS activity, as well as heat exposure-induced hypothermia and plasma ACTH and catecholamine responses in aged rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 147396-10-9
Molecular Weight 1224.58
Formula C₅₅H₉₇N₁₅O₁₂S₂
Sequence Shortening

KTKCKFLKKC (Disulfide bridge: Cys4-Cys10)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Toshihiko Katafuchi, et al. Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats. Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):24-32. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References

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Endotoxin inhibitor

All COX Isoforms

All Interleukin Related Isoforms