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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
Gck
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "Gck" in MCE Product Catalog:
Cat. No.: HY-189292
Research Areas:
HK2-IN-5 is a selective hexokinase 2 (HK2) inhibitor with an IC50 of 1.17 μM against HK2 enzymatic activity. HK2-IN-5 shows weak inhibition against HK3 and GCK (HK4). By inhibiting HK2, HK2-IN-5 induces a decrease in mitochondrial membrane potential (ΔΨm) and accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction and oxidative stress, and its antiproliferative effect is mainly dependent on HK2. HK2-IN-5 can be used in research related to triple-negative breast cancer .
Cat. No.: HY-147141A
Research Areas:
HS-276 hydrochloride is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 hydrochloride shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 hydrochloride reduces the expression of TNF, IL-6, and IL-1β. HS-276 hydrochloride can be used for rheumatoid arthritis (RA) research .
Cat. No.: HY-147141B
Research Areas:
HS-276 formic is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 formic shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 formic reduces the expression of TNF, IL-6, and IL-1β. HS-276 formic can be used for rheumatoid arthritis (RA) research .
Cat. No.: HY-P81378A
Synonyms: MAP4K4; HGK, KIAA0687, NIK; Mitogen-activated protein kinase kinase kinase kinase 4; HPK/Gck-like kinase HGK; MAPK/ERK kinase kinase kinase 4 (MEK kinase kinase 4; MEKKK 4); Nck-interacting kinase
Cat. No.: HY-P71677
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FAM20C; Golgi-Enriched Fraction Casein Kinase; FAM20C Golgi Associated Secretory Pathway Kinase; IMAGE:4942737; DMP4; DKFZp547D065; Dentin Matrix Protein 4; GEF-CK; Golgi Casein Kinase; DMP-4; G-CK; FAM20C, Golgi Associated Secretory Pathway Kinase; Extra
Species:
Human
Source:
HEK293
Cat. No.: HY-P702743
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MAP4K4; Non-Specific Serine/Threonine Protein Kinase; Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4; Epididymis Secretory Protein Li 31; HGK; Ste20 Group Protein Kinase HGK; NIK; Uncharacterized Protein MAP4K4; FLH21957; HPK/Gck-Like Kinase; Hep
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
