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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
48 Results for "
Pim2
" in MedChemExpress (MCE) Product Catalog:
Products (48)
48 Results for "Pim2" in MCE Product Catalog:
Cat. No.: HY-115590
CAS No.: 1902983-63-4
JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 (IC50 = 0.5 nM). JP11646 is freely reversible and ATP non-competitive. JP-11646 results in a decrease of PIM1, 2, and 3 mRNA. JP-11646 can effectively inhibit cell viability in small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas of the lung (LCNEC). JP-11646 can cause a decrease in p-4EBP-1 protein, increasing the cleavage of caspases while decreasing caspase-3. JP-11646 induces apoptosis or necroptosis in cells. JP-11646 leads to reductions in MYC paralogs. JP-11646 can be used for the study of SCLC, LCNEC, human acute leukemia (AML), multiple myeloma (MM), and triple-negative breast cancer (TNBC) [2] .
Cat. No.: HY-RS10551
Target:
Research Areas:
Pim2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pim2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
MNK inhibitor 9 is a potent and selective inhibitor of MNK1/2 with IC50 values of 0.003 µM and 0.003 µM for MNK1 and MNK2 respectively. MNK inhibitor 9 has good cell permeability. MNK inhibitor 9 can be used in tumor related research .
Cat. No.: HY-164460
CAS No.: 1204181-93-0
AZD1897 is a PIM1, PIM2, and PIM3 inhibitor with IC50 values of less than 3 nM for these three PIM kinases. AZD1897 exhibits anticancer activity and synergistically inhibits the activity of acute myeloid leukemia (AML) cells in combination with Capivasertib (HY-15431). This synergistic inhibitory effect is achieved through the inhibition of the mTOR and MCL1 pathways [2].
Cat. No.: HY-RS10550
Target:
Research Areas:
PIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for PIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS10552
Target:
Research Areas:
Pim2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Pim2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-13287A
CAS No.: 1173928-26-1
Research Areas:
SGI-1776 is an inhibitor of Pim kinases, with IC50s of 7 nM, 363 nM, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively [2] .
CDDO-2P-Im is an analogue of CDDO-Imidazolide with chemopreventive effect. CDDO-2P-Im can reduce the size and the severity of the lung tumors in mouse lung cancer model .
Cat. No.: HY-157404
CAS No.: 2918764-16-4
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .
Cat. No.: HY-P701746
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Pim2; Pim-2h; Pim-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene Pim-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase Pim-2; Non-Specific Serine/Threonine Protein Kinase; Pim-2 Oncogene
Species:
Human
Source:
E. coli
Cat. No.: HY-P701747
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Pim2; Pim-2h; Pim-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene Pim-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase Pim-2; Non-Specific Serine/Threonine Protein Kinase; Pim-2 Oncogene
Species:
Human
Source:
E. coli
Cat. No.: HY-P706086
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Pim2; Pim-2h; Pim-2 Proto-Oncogene, Serine/Threonine Kinase; Proto-Oncogene Pim-2 (Serine Threonine Kinase); Serine/Threonine-Protein Kinase Pim-2; Non-Specific Serine/Threonine Protein Kinase; Pim-2 Oncogene
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-163442A
PIM3-IN-1 hydrochloride (Compound 19a) is an inhibitor of (PIM2/3), with the highest inhibition level being against PIM3, having an IC50 value in the nanomolar range. PIM3-IN-1 hydrochloride can be used in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
