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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
SLP 1
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "SLP 1" in MCE Product Catalog:
Target:
Research Areas:
SLP7111228 hydrochloride is a selective sphingosine kinase 1 (SphK1) inhibitor and anti-inflammatory agent. SLP7111228 hydrochloride selectively inhibits SphK1 and reduces the production of sphingosine-1-phosphate. SLP7111228 hydrochloride decreases lipopolysaccharide-induced TNFα and IL-1β levels. SLP7111228 hydrochloride alleviates obliterative pulmonary arteriopathy, increases cardiac index and decreases total pulmonary vascular resistance index. SLP7111228 hydrochloride can be used in research related to neuroinflammatory diseases and pulmonary hypertension [1] .
Cat. No.: HY-162816
PROTAC HPK1 Degrader-3 is an orally active, PROTAC degrader that selectively targets HPK1, with a DC50 of 21.26 nM. PROTAC HPK1 Degrader-3 induces HPK1 degradation via the ubiquitin-proteasome system and forms a stable ternary complex with HPK1 and CRBN. It inhibits the SLP76 and NF-κB signaling pathways, enhances MAPK signal transduction, reverses the immunosuppressive factor-mediated inhibition of T cell cytokine secretion, and promotes the secretion of T cell immune cytokines. PROTAC HPK1 Degrader-3 suppresses tumor growth and enhances anti-PD-L1-mediated antitumor activity. It can be used in studies related to malignant tumors, such as colorectal cancer [1].
Cat. No.: HY-W678610
CAS No.: 136715-68-9
Target:
Research Areas:
14-3-3γ/SLP76 degrader-1 is a stabiliser of the 14-3-3γ/phosphorylated SLP76 protein-protein interaction. 14-3-3γ/SLP76 degrader-1 lacks stabilising activity on the unrelated IL17/IL17R protein-protein interaction. 14-3-3γ/SLP76 degrader-1 lacks stabilising activity on the 14-3-3ζ/p27 protein-protein interaction. 14-3-3γ/SLP76 degrader-1 can be used for the research of autoimmune and inflammatory conditions [1].
Cat. No.: HY-165526
CAS No.: 362508-67-6
Research Areas:
S101 is an inhibitor of SLP-76 and AhR. By inhibiting SLP-76 phosphorylation, S101 blocks the TCR signaling pathway and prevents AhR nuclear translocation, thereby selectively suppressing the proliferation of activated T cells, inducing their apoptosis, and reducing TNF-α levels. S101 can be used in studies of graft rejection, psoriasis, and superantigen-induced toxic shock [1] .
Cat. No.: HY-P71320
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: LCP2; SLP-76 Tyrosine Phosphoprotein; Prev. SLP76; Lymphocyte Cytosolic Protein 2 (SH2 Domain-Containing Leukocyte Protein Of 76kD); SLP-76; SH2 Domain-Containing Leukocyte Protein Of 76kD; SH2 Domain-Containing Leukocyte Protein Of 76 KDa; IMD81; 76 KDa
Species:
Human
Source:
E. coli
Cat. No.: HY-179727
Target:
Research Areas:
PROTAC HPK1 Degrader-7 (compound D02) is a potent and selective PROTAC HPK1 degrader with an DC50 of 3.07 nM. PROTAC HPK1 Degrader-7 exhibits selectivity over GLK. PROTAC HPK1 Degrader-7 induces HPK1 degradation in a CRBN- and proteasome-dependent manner. PROTAC HPK1 Degrader-7 inhibits SLP-76 phosphorylation, induces IL-2 and IFN-γ secretion in human primary T cells. PROTAC HPK1 Degrader-7 can be used for immunology research [1].
Cat. No.: HY-P87298
Synonyms: CG8697 antibody; LCP 2 antibody; LCP2 antibody; LCP2_HUMAN antibody; Lymphocyte cytosolic protein 2 antibody; SH2 domain containing leukocyte protein 76 KD antibody; SH2 domain containing leukocyte protein of 76kD antibody; SH2 domain containing leukocyte protein of 76kDa antibody; SH2 domain-containing leukocyte protein of 76 kDa antibody; SLP 76 antibody
Cat. No.: HY-184745
Target:
Research Areas:
HPK1-IN-71 is a potent and selective HPK1 inhibitor with an IC50 of 26.3 nM. HPK1-IN-71 can inhibit the phosphorylation of SLP76, promote the secretion of IL-2 and show high selectivity for other kinases and immune-targeting kinases. HPK1-IN-71 can be used in colon cancer research [1].
Cat. No.: HY-P7667
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BLNK; Bca; B Cell Linker; Src Homology [SH2] Domain-Containing Leukocyte Protein Of 65 KD; SLP65; Src Homology 2 Domain-Containing Leukocyte Protein Of 65 KDa; BASH; B-Cell Adapter Containing A Src Homology 2 Domain Protein; SLP-65; B Cell Adaptor Contain
Species:
Human
Source:
E. coli
Cat. No.: HY-P75474
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: BLNK; Bca; B Cell Linker; Src Homology [SH2] Domain-Containing Leukocyte Protein Of 65 KD; SLP65; Src Homology 2 Domain-Containing Leukocyte Protein Of 65 KDa; BASH; B-Cell Adapter Containing A Src Homology 2 Domain Protein; SLP-65; B Cell Adaptor Contain
Species:
Human
Source:
HEK293
Cat. No.: HY-182238
CAS No.: 3095423-83-6
Target:
Research Areas:
HPK1-IN-69 is an orally active HPK1 inhibitor with an IC50 of 1.7 nM. HPK1-IN-69 inhibits the HPK1-mediated TCR signaling pathway, reduces the phosphorylation level of SLP76, and promotes the release of IL-2. HPK1-IN-69 exhibits in vivo anti-tumor activity in mouse models. HPK1-IN-69 can be used for the research of colorectal cancer and MC38 syngeneic tumors [1].
Cat. No.: HY-179338
Target:
Research Areas:
HPK1-IN-65 is a selective and orally active HPK1 inhibitor with an IC50 value of < 5 nM. HPK1-IN-65 inhibits HPK1 kinase activity and displays 1257-fold selectivity over the MAP4K kinase family member GLK. HPK1-IN-65 exhibits an IC50 of 92.3 nM for inhibiting pSLP76 phosphorylation. HPK1-IN-65 demonstrates an EC50 of 398 nM for stimulating IL-2 production. HPK1-IN-65 inhibits TCR-induced phosphorylation of SLP76 at Ser376 in a dose-dependent manner. HPK1-IN-65 can be further utilized for colorectal cancer research [1].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
