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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
40 Results for "
mitochondrial Complex II
" in MedChemExpress (MCE) Product Catalog:
Products (40)
40 Results for "mitochondrial Complex II" in MCE Product Catalog:
Art. -Nr.: HY-13721R
CAS. Nr.: 81267-65-4
Synonyms: Idronoxil (Standard); Dehydroequol (Standard); Haginin E (Standard)
Forschungsgebiete:
Phenoxodiol (Standard) is the analytical standard of Phenoxodiol. This product is intended for research and analytical applications. Phenoxodiol (Idronoxil), a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner .
Art. -Nr.: HY-113232S
CAS. Nr.: 1276197-31-9
Forschungsgebiete:
3-Methylcrotonylglycine-d2 is the deuterated-labeled 3-Methylcrotonylglycine (HY-113232). 3-Methylcrotonylglycine is an organic acid conjugate associated with leucine catabolism that inhibits respiratory chain complex II-III, mitochondrial creatine kinase, and synaptic membrane Na +, K +-ATPase. 3-Methylcrotonylglycine increases reactive oxygen species levels to mediate oxidative damage, while inhibiting mitochondrial electron transport, reducing tricarboxylic acid cycle flux, and interfering with intracellular energy transport and neuronal ion homeostasis. 3-Methylcrotonylglycine is a neurotoxic metabolite that accumulates in the metabolic pathway of 3-methylcrotonyl-CoA carboxylase deficiency. 3-Methylcrotonylglycine can be used in studies related to 3-methylcrotonyl-CoA carboxylase deficiency .
Art. -Nr.: HY-172777
CAS. Nr.: 3052432-15-9
Forschungsgebiete:
SDH-IN-25 is a succinate dehydrogenase (SDH) inhibitor (IC50 = 4.82 mg/L). SDH-IN-25 exhibited broad-spectrum and potent antifungal activity. SDH-IN-25 mimics the interaction pattern of commercial fungicide Fluxapyroxad (HY-135549) through binding to SDH amino acid residues (TRP173, TYR58, and ARG43). SDH-IN-25 can induce hyphal morphology, interfere with respiratory metabolism by binding to complex II, generate reactive oxygen species (ROS), and affect mitochondrial membrane potential (MMP) in mycelia. SDH-IN-25 can be studied in research for agricultural disease control .
Art. -Nr.: HY-B2004R
CAS. Nr.: 130000-40-7
Forschungsgebiete:
Thifluzamide (Standard) is the analytical standard of Thifluzamide. This product is intended for research and analytical applications. Thifluzamide is a fungicide that inhibits fungal respiration by blocking the ubiquinone-binding site in mitochondrial complex II. Thifluzamide exhibits significant activity against Basidiomycota pathogens (such as Rhizoctonia cerealis, Ustilago and Puccinia genera) and is commonly used in studies on wheat sharp eyespot. Thifluzamide displays a dual mechanism in regulating lipid metabolism: it reduces fatty acid synthase activity to inhibit endogenous fatty acid synthesis, and increases carnitine palmitoyltransferase-I activity to accelerate fatty acid β-oxidation, thereby reducing total cholesterol and triglyceride levels in the liver. Thifluzamide also induces hepatotoxicity in zebrafish models and carries a risk of developmental toxicity. Thifluzamide inhibition of Rhizoctonia cerealis may result in low to moderate levels of drug resistance, leading to the generation of stable drug-resistant mutants .
Art. -Nr.: HY-W719544
CAS. Nr.: 560121-52-0
Cyenopyrafen is a mitochondrial complex II inhibitor and acaricide. Cyenopyrafen controls spider mites on fruit trees, vegetables and flowers .
Art. -Nr.: HY-W019824
CAS. Nr.: 762-29-8
Category:
Art. -Nr.: HY-187649
CAS. Nr.: 2696100-70-4
Target:
Forschungsgebiete:
FLAD1-IN-1 is a FLAD1 inhibitor. FLAD1-IN-1 impairs the activity of mitochondrial complex II by disrupting the intracellular FAD pool, thereby inducing cellular mitochondrial dysfunction and reducing hypoxic tolerance. FLAD1-IN-1 exhibits anticancer activity against hypoxic tumors. FLAD1-IN-1 can be used in the research of lung cancer .
Art. -Nr.: HY-P11743
Forschungsgebiete:
Art. -Nr.: HY-182534
CAS. Nr.: 2110408-47-2
Target:
Forschungsgebiete:
Succinate dehydrogenase-IN-12 is a selective inhibitor of mitochondrial complex II (succinate dehydrogenase), with an IC50 value of 3.3 nM. Succinate dehydrogenase-IN-12 can be used for tumor research .
Art. -Nr.: HY-P87067
Synonyms: CYB560 antibody; C560_HUMAN antibody; CYBL antibody; Cytochrome B large subunit of Complex II antibody; Integral membrane protein CII-3 antibody; mitochondrial antibody; PGL3 antibody; QPs-1 antibody; QPs1 antibody; SDH3 antibody; CYB560 antibody; C560_HUMAN antibody; CYBL antibody; Cytochrome B large subunit of Complex II antibody; Integral membrane protein CII-3 antibody; mitochondrial antibody; PGL3 antibody; QPs-1 antibody; QPs1 antibody; SDH3 antibody; sdhC antibody; succinate dehydrgenase cytochrome b antibody; succinate dehydrogenase 3, integral membrane subunit antibody; Succinate dehydrogenase Complex subunit C antibody; Succinate dehydrogenase Complex subunit C integral membrane protein 15kDa antibody; Succinate dehydrogenase cytochrome b560 subunit antibody; Succinate dehydrogenase cytochrome b560 subunit mitochondrial antibody; Succinate dehydrogenase cytochrome b560 subunit, mitochondrial precursor antibody; Succinate-ubiquinone oxidoreductase cytochrome B large subunit antibody;
Art. -Nr.: HY-105904
CAS. Nr.: 54824-20-3
Forschungsgebiete:
Pinafide is an orally active anticancer agent. Pinafide binds to double-stranded DNA via intercalation, stabilizes the DNA-topoisomerase II complex, induces photo-induced DNA damage and ROS production, causes lysosomal and mitochondrial dysfunction, impairs DNA and RNA synthesis, and blocks cell growth. Pinafide binds to human serum albumin in vitro, undergoes biotransformation via reduction and acetylation in rats, and can cross the placental barrier of pregnant rats. Pinafide can be used in cancer-related research such as hepatocellular carcinoma .
Art. -Nr.: HY-183549
Target:
Forschungsgebiete:
Ferroptosis/apoptosis inducer-4 is a pyridine-hydrazone-derived Cu (II) complex and a synergistic inducer of ferroptosis and apoptosis. Ferroptosis/apoptosis inducer-4 exerts anti-tumor proliferation and anti-metastasis effects with extremely low systemic toxicity. Ferroptosis/apoptosis inducer-4 disrupts cellular redox homeostasis by depleting glutathione and generating hydroxyl radicals through the Cu 2+/Cu + redox cycle. Ferroptosis/apoptosis inducer-4 also triggers mitochondrial dysfunction and endoplasmic reticulum stress, which in turn lead to Ca 2+ release, mitochondrial Ca 2+ overload, and the formation of a ROS−Ca 2+ self-amplifying feedback loop. Ferroptosis/apoptosis inducer-4 can be used in studies related to cervical cancer .
Art. -Nr.: HY-P704801
Reinheit: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SDHA; Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit; Prev. SDH2; CMD1GG; SDHF; MC2DN1; Succinate Dehydrogenase [Ubiquinone] Flavoprotein Subunit, mitochondrial; NDAXOA; Flavoprotein Subunit Of Complex II; PPGL5; FP; PGL5; Succinate Dehydrogena
Species:
Human
Source:
E. coli
Art. -Nr.: HY-187992
Target:
Forschungsgebiete:
SDH-IN-48 is a succinate dehydrogenase (SDH) inhibitor, with an IC50 of 0.056 μM against porcine SDH. SDH-IN-48 binds to the SDH active pocket through multiple non-covalent interactions. SDH-IN-48 can be used in related research on rice sheath blight disease .
Art. -Nr.: HY-W727481
CAS. Nr.: 1253429-01-4
Target:
Forschungsgebiete:
Cyetpyrafen is a pyrazole insecticide/acaricide with broad-spectrum insecticidal activity. Cyetpyrafen binds to DhelOBP4 (Ki = 4.95 μM) and DhelOBP21 (Ki = 5.51 μM) to mediate olfactory recognition in *Cryptolaemus montrouzieri*. Cyetpyrafen induces dose-dependent electroantennogram responses in *Cryptolaemus montrouzieri* and exhibits repellent effects on the species. Cyetpyrafen has bioaccumulative properties, is rapidly and passively absorbed by the roots of lettuce and rice, reaches a steady state within 24 h, preferentially accumulates in roots, and shows limited xylem/phloem translocation .
Art. -Nr.: HY-138439
CAS. Nr.: 173662-97-0
Target:
Forschungsgebiete:
Mandestrobin is a fungicide that exerts fungal killing activity by inhibiting mitochondrial respiratory chain complex III. Mandestrobin exhibits differential fungicidal activity between its enantiomers, and the R-enantiomer possesses stronger activity than the S-enantiomer. Mandestrobin is used in studies related to fungal infections and the agricultural field .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
