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製品番号: HY-105904

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Pinafide

Pinafide is an orally active anticancer agent. Pinafide binds to double-stranded DNA via intercalation, stabilizes the DNA-topoisomerase II complex, induces photo-induced DNA damage and ROS production, causes lysosomal and mitochondrial dysfunction, impairs DNA and RNA synthesis, and blocks cell growth. Pinafide binds to human serum albumin in vitro, undergoes biotransformation via reduction and acetylation in rats, and can cross the placental barrier of pregnant rats. Pinafide can be used in cancer-related research such as hepatocellular carcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 54824-20-3
分子式: C₁₈H₁₇N₃O₄
分子量:339.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pinafide 構造式

CAS 番号: 54824-20-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC50	1.23 μM	Antiproliferative activity against human hepatocellular carcinoma HepG2 cells assessed as inhibition of cell growth by MTT tetrazolium dye assay. Antiproliferative activity against human hepatocellular carcinoma HepG2 cells assessed as inhibition of cell growth by MTT tetrazolium dye assay.	33803403

体外実験

Pinafide (10-50 μg/mL) binds to human serum albumin, with one high-affinity, low-binding-capacity site (K₁ = 2.8×10⁶ M^-1) and one moderate-affinity, high-binding-capacity site (K₂ = 5.3×10³ M^-1)^[1].
Pinafide is a classic DNA intercalator that stabilizes calf thymus DNA, with a ΔT_m of 6.50 °C and a binding constant of 6.60 × 10⁴ M^-1^[2].
Pinafide potently inhibits the proliferation of human hepatocellular carcinoma HepG2 cells, with an IC₅₀ value of 1.23 μM; when applied at the IC₅₀ concentration of 1.23 μM, it induces G2/M phase cell cycle arrest in human hepatocellular carcinoma HepG2 cells^[2].
Pinafide (0.615 μM; 24 h) induces reactive oxygen species production in human hepatocellular carcinoma HepG2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Pinafide (20 mg/kg; i.v.; single bolus; p.o.; single dose) exhibits biphasic plasma disposition after i.v. administration, nearly complete oral bioavailability, and undergoes biotransformation via reduction and acetylation in healthy female Sprague-Dawley rats^[1].
Pinafide (10 mg/kg; i.v.; single bolus) crosses the placental barrier in pregnant Sprague-Dawley rats, with fetus and amniotic fluid concentrations exceeding or matching maternal blood concentrations 1 hour after i.v. administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 54824-20-3
分子量 339.35
分子式 C₁₈H₁₇N₃O₄
SMILES

O=C1C2=C3C(C(N1CCN4CCCC4)=O)=CC([N+]([O-])=O)=CC3=CC=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Rivera Cid P, et al. The pharmacokinetics, tissue distribution, and biotransformation of a new class of antitumor agents: mitonafide and pinafide. European journal of drug metabolism and pharmacokinetics. 1986;11(4):255-67.

[2]. Rykowski S, et al. Design, Synthesis, and Evaluation of Novel 3-Carboranyl-1,8-Naphthalimide Derivatives as Potential Anticancer Agents. International journal of molecular sciences. 2021 Mar 09;22(5):2772.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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