Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
47 Results for "
DNA dimer
" in MedChemExpress (MCE) Product Catalog:
Products (47)
47 Results for "DNA dimer" in MCE Product Catalog:
Cat. No.: HY-126678
CAS No.: 3026416-27-0
Synonyms: Dimethyl-PBD dimer
Target:
Research Areas:
Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly potent DNA alkylator, and is used as an antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylator which inhibits DNA replication .
Cat. No.: HY-125636
CAS No.: 313987-85-8
Mycro1 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC50 value of 30 μM for the inhibition of Myc/Max DNA binding activity. Mycro1 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation .
Cat. No.: HY-24144
CAS No.: 1430738-34-3
Target:
Research Areas:
Tesirine intermediate-2 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Cat. No.: HY-47820
CAS No.: 1430738-05-8
Target:
Research Areas:
Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Cat. No.: HY-128952G
CAS No.: 1595275-62-9
Synonyms: SG3249 (GMP)
Cat. No.: HY-P3223A
Target:
Research Areas:
Cat. No.: HY-W013059R
CAS No.: 98796-53-3
Synonyms: DA-CE phosphoramidite (Standard)
Target:
Research Areas:
DMT-dA(bz) Phosphoramidite (Standard) is the analytical standard of DMT-dA(bz) Phosphoramidite. This product is intended for research and analytical applications. DMT-dA(bz) Phosphoramidite is a phosphoramide monomer for the synthesis of oligonucleotides (ONs) through formation of DNA dimers and trimers via mechanochemistry .
Cat. No.: HY-E70371
CAS No.: 1943614-02-5
Target:
Research Areas:
Cre recombinase is a resolvase derived from the P1 bacteriophage. Cre recombinase catalyzes site-specific recombination between two loxP DNA sequences, converts dimers of P1 chromosome into monomers before cell division. Cre recombinase is utilized in genetic engineering and molecular biology applications .
Cat. No.: HY-W008848S1
Cat. No.: HY-W040129R
CAS No.: 7059-24-7
Category:
Cat. No.: HY-P3223
CAS No.: 126872-95-5
Target:
Research Areas:
Cat. No.: HY-101161R
CAS No.: 1595275-71-0
Research Areas:
SG3199 (Standard) is the analytical standard of SG3199 (HY-101161). This product is intended for research and analytical applications. SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PBD) dimer. SG3199 is the released warhead component of the ADC payload Tesirine (SG3249) .
Cat. No.: HY-185488
CAS No.: 2592397-70-9
Research Areas:
seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma .
Cat. No.: HY-185494
CAS No.: 1661824-39-0
Research Areas:
Mal-Val-Lys-PAB-CBI-PBD dimer is a Drug-Linker Conjugates for ADC. Mal-Val-Lys-PAB-CBI-PBD dimer consists of the ADC Cytotoxin CBI-PBD dimer and a linker Mal-Val-Lys-PAB. Mal-Val-Lys-PAB-CBI-PBD dimer exhibits alkylating activity at A-T-rich DNA minor groove adenine residues, disrupting DNA integrity. Mal-Val-Lys-PAB-CBI-PBD dimer induces cancer cell growth inhibition and cellular death. Mal-Val-Lys-PAB-CBI-PBD dimer can be used for the research of cancer .
Cat. No.: HY-185493
CAS No.: 1661823-95-5
Target:
Research Areas:
Mal-VC-PAB-seco-CBI-PBD dimer is a highly active drug-linker conjugate. Mal-VC-PAB-seco-CBI-PBD dimer integrates the DNA-damaging effects of two distinct types of compounds: seco-cyclopropabenzindoline (seco-CBI) and pyrrolobenzodiazepine (PBD). Mal-VC-PAB-seco-CBI-PBD dimer is linked via a valine-alanine (VC) linker cleavable by cathepsin B and achieves targeted delivery relying on monoclonal antibodies. Mal-VC-PAB-seco-CBI-PBD dimer is applicable for cancer research .
Cat. No.: HY-171718
CAS No.: 550356-40-6
Research Areas:
seco-CBI-PBD dimer is a CBI-PBD heterodimer and a minor groove DNA crosslinker. seco-CBI-PBD dimer exhibits cytotoxicity against human tumor cells at sub-pM to low nM levels, shows low sensitivity to P-glycoprotein-mediated drug resistance, and can serve as an ADC payload. seco-CBI-PBD dimer can be used in studies of uterine cancer, breast cancer, non-small cell lung cancer, etc.
Cat. No.: HY-185492
CAS No.: 1799659-90-7
Research Areas:
MC-cBu-Cit-seco-CBI dimer (Compound 10) is a conjugate of an ADC drug toxin molecule and a linker, which consists of a DNA alkylating agent connected to a reactive maleimide via a protease-cleavable peptidomimetic linker .
Cat. No.: HY-101160R
CAS No.: 260417-62-7
Synonyms: DRG16 (Standard)
Research Areas:
SG2057 (Standard) is the analytical standard of SG2057 (HY-101160). This product is intended for research and analytical applications. SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .
Cat. No.: HY-101161S
Cat. No.: HY-122715
CAS No.: 1971075-99-6
Target:
Research Areas:
(S,S)-D211 is a stereoisomer of D211. (S,S)-D211 belongs to PBD dimer family with DNA damage activity. (S,S)-D211 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
