2. Cell Cycle/DNA Damage Antibody-drug Conjugate/ADC Related
  3. DNA Alkylator/Crosslinker ADC Payload
  4. seco-CBI dimer

seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma.

For research use only. We do not sell to patients.

seco-CBI dimer

seco-CBI dimer Chemical Structure

CAS No. : 2592397-70-9

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seco-CBI dimer Related Antibodies

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Description

seco-CBI dimer is a DNA alkylating agent and a prodrug of Duocarmycin, which can serve as a payload for synthesizing antibody-drug conjugates (ADCs). seco-CBI dimer binds to the minor groove of A-T-rich regions in DNA, alkylates the N3 position of adenine residues, and induces DNA strand breaks. seco-CBI dimer can be used in the research of non-Hodgkin's lymphoma[1].

In Vitro

seco-CBI dimer-based ADCs potently inhibit the growth of CD22-positive lymphoma cells in vitro, with IC50 values ranging from 10 to 80 pM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

seco-CBI dimer Related Antibodies
Molecular Weight

735.65

Formula

C41H36Cl2N4O5
CAS No.
SMILES

ClC[C@@H]1CN(C2=C1C3=C(C(O)=C2)C=CC=C3)C(/C=C/C4=C(C=C(C=C4)/C=C/C(N5C6=C([C@@H](C5)CCl)C7=C(C(O)=C6)C=CC=C7)=O)NC(CCN)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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seco-CBI dimer Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

seco-CBI dimer2592397-70-9DNA Alkylator/CrosslinkerADC PayloadADC Cytotoxinα1-microglobulincynomolgus monkeysA-T-rich regionslymphoma cellsadenine residuesDNA minor groovelymphoma xenograft modelspinatuzumab-vedotin-resistant tumorsnon-hodgkin lymphomaCD22-positive lymphoma cellInhibitorinhibitorinhibit

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seco-CBI dimer
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