Tesirine intermediate-1
Based on 1 Customer Validation
Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
For research use only. We do not sell to patients.
- Purity: 99.41%
- CAS No.: 1430738-05-8
- Formula: C28H48N2O7Si2
- Molecular Weight:580.86
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1430738-05-8
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Appearance Solid
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Molecular Weight 580.86
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Formula C28H48N2O7Si2
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Color White to off-white
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SMILES
CC(C)[Si](C(C)C)(C(C)C)OC1=C(C=C(C([N+]([O-])=O)=C1)C(N2[C@@H](CC(C2)=O)CO[Si](C)(C)C(C)(C)C)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (172.16 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7216 mL | 8.6079 mL | 17.2159 mL | 43.0396 mL |
| 5 mM | 0.3443 mL | 1.7216 mL | 3.4432 mL | 8.6079 mL | |
| 10 mM | 0.1722 mL | 0.8608 mL | 1.7216 mL | 4.3040 mL | |
| 15 mM | 0.1148 mL | 0.5739 mL | 1.1477 mL | 2.8693 mL | |
| 20 mM | 0.0861 mL | 0.4304 mL | 0.8608 mL | 2.1520 mL | |
| 25 mM | 0.0689 mL | 0.3443 mL | 0.6886 mL | 1.7216 mL | |
| 30 mM | 0.0574 mL | 0.2869 mL | 0.5739 mL | 1.4347 mL | |
| 40 mM | 0.0430 mL | 0.2152 mL | 0.4304 mL | 1.0760 mL | |
| 50 mM | 0.0344 mL | 0.1722 mL | 0.3443 mL | 0.8608 mL | |
| 60 mM | 0.0287 mL | 0.1435 mL | 0.2869 mL | 0.7173 mL | |
| 80 mM | 0.0215 mL | 0.1076 mL | 0.2152 mL | 0.5380 mL | |
| 100 mM | 0.0172 mL | 0.0861 mL | 0.1722 mL | 0.4304 mL |
Tesirine intermediate-1 Related Classifications
HY-47820 Related Classifications
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