Tesirine intermediate-1

Cat. No.: HY-47820 Purity: 99.41%: FAQs
Data Sheet SDS COA Handling Instructions

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Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.

For research use only. We do not sell to patients.

Tesirine intermediate-1 Chemical Structure

CAS No. : 1430738-05-8

Size	Price	Stock	Quantity
1 mg	USD 230	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 510	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 820	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1730	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2770	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4440	In-stock	Estimated Time of Arrival: December 31
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Description	Tesirine intermediate-1 is the intermediate of Tesirine (HY-128952). Tesirine (SG3249), a pyrrole benzodiazepine (PBD) dimer, is a DNA small channel crosslinker with strong cytotoxicity. Tesirine can be used to synthesize Antibody-Drug Conjugates (ADCs), the warhead component of the payload is SG3199 (HY-101161), which has strong anticancer cell activity.
Molecular Weight	580.86
Formula	C₂₈H₄₈N₂O₇Si₂
CAS No.	1430738-05-8
Appearance	Solid
Color	White to off-white
SMILES	CC(C)[Si](C(C)C)(C(C)C)OC1=C(C=C(C([N+]([O-])=O)=C1)C(N2[C@@H](CC(C2)=O)CO[Si](C)(C)C(C)(C)C)=O)OC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation	Purity: 99.41% Select Batch: Data Sheet (272 KB) SDS (393 KB) COA (230 KB) HNMR (276 KB) LCMS (108 KB) Handling Instructions (2659 KB)
References	[1]. Howard, et al. Process for the preparation of intermediates useful for the synthesis of pyrrolobenzodiazepine dimers. World Intellectual Property Organization, WO2013053872 A1. 2013-04-18. [2]. Tiberghien AC, et al. Design and Synthesis of Tesirine, a Clinical Antibody-Drug Conjugate Pyrrolobenzodiazepine Dimer Payload. ACS Med Chem Lett. 2016;7(11):983-987. Published 2016 May 24. [Content Brief]