4988 Results for "

expression

" in MedChemExpress (MCE) Product Catalog:
Products (4988)

4988 Results for "expression" in MCE Product Catalog:

Hydroxytyrosol acetate
Hydroxytyrosol acetate
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Referencia número: HY-N6043
No. CAS: 69039-02-7
Category:  

Canarium album (Lour.) Rauesch. Phenols Polyphenols Plants Burseraceae Disease Research Fields Inflammation/Immunology

Target:  

Free Radical Scavengers Apoptosis Reactive Oxygen Species (ROS) Bacterial SARS-CoV Estrogen Receptor/ERR

Hydroxytyrosol acetate is an orally active, blood-brain barrier-permeable multi-active compound with multiple effects including antibacterial, antioxidant, anti-platelet aggregation, and neuroprotective activities. Hydroxytyrosol acetate not only inhibits the growth of Vibrio by increasing bacterial membrane permeability, but also interacts with DNA and mediates supercoiled DNA relaxation. Meanwhile, Hydroxytyrosol acetate effectively reduces thrombosis and inhibits lipid oxidation by inhibiting COX activity and promoting vascular nitric oxide production. In terms of neuroprotection, Hydroxytyrosol acetate significantly alleviates neuronal apoptosis and inflammatory responses by up-regulating the expression level of ERβ, thereby improving cognitive function in Alzheimer's disease models. Hydroxytyrosol acetate has been widely used in scientific research related to Vibrio infection, arterial thrombosis, Alzheimer's disease and other related fields .
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Citrinin-13C13
Citrinin-13C13
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Referencia número: HY-N6746S1
Synonyms: NSC 186-13C13
Citrinin- 13C13 (NSC 186- 13C13) is the 13C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .
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Neosolaniol
Neosolaniol
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Referencia número: HY-N6799
No. CAS: 36519-25-2
Category:  

Infection Microorganisms Terpenoids Sesquiterpenes Disease Research Fields

Target:  

Caspase Bcl-2 Family Apoptosis Reactive Oxygen Species (ROS)

Neosolaniol is an orally active type A trichothecene mycotoxin, and it is a metabolite of T-2 Toxin (HY-N6792) in human cancer cells and renal epithelial cells. Neosolaniol targets Bax, Bcl-2, caspase 3, caspase 8, and cytochrome c, thereby inducing apoptosis, emesis and anorexia. Neosolaniol reduces intracellular ATP levels, elevates ROS levels, decreases mitochondrial membrane potential, induces mitochondrial damage, and exerts toxicity on Leydig cells. Neosolaniol downregulates the expression of intestinal tight junction proteins in broilers and increases the load of Salmonella enteritidis in the cecum of broilers. Neosolaniol can be used in research related to anorexia, lymphoma, Fusarium melonis rot, and Salmonella infection .
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Iminostilbene
Iminostilbene
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Referencia número: HY-N7064
No. CAS: 256-96-2
Target:  

Pyruvate Kinase COX STAT TNF Receptor NO Synthase Interleukin Related HIF/HIF Prolyl-Hydroxylase

Áreas de investigación:  

Cardiovascular Disease Inflammation/Immunology

Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3, reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β, IL-6, TNF-α, and MCP-1, thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases .
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Homoeriodictyol (Standard)
Homoeriodictyol (Standard)
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Referencia número: HY-N8210R
No. CAS: 446-71-9
Category:  

other families Flavonoids Flavonones Phenols Polyphenols Plants

Target:  

Reference Standards Drug Metabolite Autophagy Apoptosis Reactive Oxygen Species (ROS) Keap1-Nrf2 MMP Caspase PARP MDM-2/p53

Homoeriodictyol (Standard) is the analytical standard of Homoeriodictyol (HY-N8210). This product is intended for research and analytical applications. Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo .
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Hecubine
Hecubine
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Referencia número: HY-N9164
No. CAS: 62874-52-6
Category:  

Apocynaceae Alkaloids Piperidine Alkaloids Tabernaemontana bufalina Lour. Plants

Target:  

TREM receptor Toll-like Receptor (TLR) MyD88 NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TNF Receptor Interleukin Related p38 MAPK PI3K Akt Reactive Oxygen Species (ROS)

Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases .
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HYNIC-H6F
HYNIC-H6F
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Referencia número: HY-P10792A
Target:  

EGFR

Áreas de investigación:  

Cancer

HYNIC-H6F is a SPECT imaging probe with binding specificity for human epidermal growth factor receptor 2 (HER2) domain II (IC50 = 11 nM). HYNIC-H6F accumulates in HER2-positive breast cancer xenografts via receptor-mediated uptake, while shows low uptake in HER2-negative breast cancer xenografts. HYNIC-H6F enables non-invasive detection of HER2-positive breast cancer in mouse models and allows evaluation of HER2 expression levels without blocking interference. HYNIC-H6F can be used in breast cancer-related research .
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Tat-IKIP (46-60) TFA
Tat-IKIP (46-60) TFA
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Referencia número: HY-P10966A
Target:  

IKK NF-κB

Áreas de investigación:  

Inflammation/Immunology

Tat-IKIP (46-60) TFA is the trifluoroacetic acid of Tat-IKIP (46-60) (HY-P10966). Tat-IKIP (46-60) is a IκB kinase (IKK)-targeting membrane-penetrating peptide. Tat-IKIP (46-60) inhibits IKK activation and NF-κB targeted gene expression by disrupting the IKKβ/NEMO complex. Tat-IKIP (46-60) significantly reduces DSS (HY-116282)-induced acute inflammation in inflammatory bowel disease (IBD) mice model and attenuates Zymosan-induced acute arthritis in acute arthritis model (AAM). Tat-IKIP (46-60) can be used for inflammatory diseases research, such as IBD, pancreatitis and rheumatoid arthritis .
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NNC0165-1273
NNC0165-1273
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Referencia número: HY-P11291
Target:  

Neuropeptide Y Receptor

Áreas de investigación:  

Metabolic Disease

NNC0165-1273 is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 blocks Ghrelin-induced cFos expression. NNC0165-1273 reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 can be used in studies related to diet-induced obesity .
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NNC0165-1273 acetate
NNC0165-1273 acetate
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Referencia número: HY-P11291B
Target:  

Neuropeptide Y Receptor

Áreas de investigación:  

Metabolic Disease

NNC0165-1273 acetate is a selective NPY Y2 receptor agonist with a Ki of 2 nM and an EC50 of 5.0 nM. NNC0165-1273 acetate blocks Ghrelin-induced cFos expression. NNC0165-1273 acetate reduces nocturnal food intake, attenuates feeding behavior, induces early satiety, and causes dose-dependent decreases in body weight and fat mass in diet-induced obese mice. When used in combination with Semaglutide (HY-114118), NNC0165-1273 acetate reduces preference for high-fat diet, promotes body weight loss, and produces sustained weight loss effects in diet-induced obese rats. NNC0165-1273 acetate can be used in studies related to diet-induced obesity .
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Gy-CATH
Gy-CATH
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Referencia número: HY-P11467
Target:  

Bacterial p38 MAPK NF-κB PERK JNK

Áreas de investigación:  

Cardiovascular Disease Infection

Gy-CATH is an anionic antimicrobial peptide. Gy-CATH activates MAPK and NF-κB signaling pathways (elevated levels of phospho-ERK, -p38, -JNK, -p65, and -IκBα). Gy-CATH upregulates the expression levels of three physiological anticoagulant pathways. Gy-CATH inhibits ADP-, Collagen-, and PMA-induced platelet aggregation. Gy-CATH has no direct antimicrobial activity, but shows significant preventive abilities against mice infected with Staphylococcus aureus, Escherichia coli, and Methicillin (HY-121544)-resistant Staphylococcus aureus. Gy-CATH exhibits potent immunomodulatory activity, enhancing macrophage-and neutrophil-mediated bactericidal functions. Gy-CATH significantly reduces the extent of pulmonary fibrin deposition and prevents thrombosis in mice .
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cRY9M
cRY9M
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Referencia número: HY-P11853
Target:  

FGFR Radionuclide-Drug Conjugates (RDCs)

Áreas de investigación:  

Cancer

cRY9M is a cyclic peptide that binds to FGFR1, with a KD value of 58 nM. cRY9M binds specifically to FGFR1, exhibits enhanced in vivo stability, and shows extremely low degradation in blood, urine and liver homogenate after injection. cRY9M displays significant specific uptake in FGFR1-positive tumor xenograft models, while its uptake decreases in FGFR1-negative tumor models and blocking models. The NOTA-chelated precursor of cRY9M can be labeled with 68Ga to obtain [ 68Ga]Ga-NOTA-cRY9M, which is used for research on non-invasive imaging of FGFR1 expression in non-small cell lung cancer .
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cRY9M acetate
cRY9M acetate
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Referencia número: HY-P11853A
Target:  

FGFR Radionuclide-Drug Conjugates (RDCs)

Áreas de investigación:  

Cancer

cRY9M acetate is a cyclic peptide that binds to FGFR1, with a KD value of 58 nM. cRY9M acetate binds specifically to FGFR1, exhibits enhanced in vivo stability, and shows extremely low degradation in blood, urine and liver homogenate after injection. cRY9M acetate displays significant specific uptake in FGFR1-positive tumor xenograft models, while its uptake decreases in FGFR1-negative tumor models and blocking models. The NOTA-chelated precursor of cRY9M acetate can be labeled with 68Ga to obtain [ 68Ga]Ga-NOTA-cRY9M, which is used for research on non-invasive imaging of FGFR1 expression in non-small cell lung cancer .
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Siamycin I
Siamycin I
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Referencia número: HY-P2200
No. CAS: 164802-68-0
Synonyms: BMY-29304
Target:  

HIV Antibiotic

Áreas de investigación:  

Infection Inflammation/Immunology

Siamycin I (BMY-29304), a 21-residue tricyclic peptide, is a secondary metabolite in actinomycetes. Siamycin I is a HIV fusion inhibitor with ED50s of 0.05 to 5.7 μM for acute HIV type 1 (HIV-1) and HIV-2 infections. Siamycin I inhibits the gelatinase and gelatinase biosynthesis-activating pheromone (GBAP) signaling via the FsrC-FsrA two-component regulatory system in a noncompetitive manner. Siamycin I suppresses the expression of both fsrBDC and gelE-sprE transcripts. Siamycin I, a lasso peptide, interacts with lipid II and inhibits cell wall biosynthesis. Siamycin I, an antibiotic, has the potential for enterococcal infections research .
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Glycerol kinase, microorganism
Glycerol kinase, microorganism
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Referencia número: HY-P2917
No. CAS: 9030-66-4
Synonyms: GyK
Target:  

Nuclear Hormone Receptor 4A/NR4A

Áreas de investigación:  

Metabolic Disease Inflammation/Immunology

Glycerol kinase, microorganism (GyK) acts as a NR4A1 inhibitor with enzymatic activity. It directly binds to and inhibits the transcription factor NR4A1, thereby negatively regulating hepatic gluconeogenesis and reducing blood glucose levels. Glycerol kinase, microorganism positively regulates UCP1 expression via partial dependence on the β-adrenergic receptor-cAMP-CREB pathway, promotes browning of white adipose tissue and thermogenesis, and further modulates intracellular fatty acid composition and energy metabolism. In diabetic mouse models, overexpression of Glycerol kinase effectively antagonizes NR4A1-induced hyperglycemia, demonstrating potential for improving glucose homeostasis. Glycerol kinase, microorganism can be used for studies on diabetes and obesity .
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L17E
L17E
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Referencia número: HY-P4121
No. CAS: 1898254-09-5
Target:  

Potassium Channel

Áreas de investigación:  

Inflammation/Immunology Cancer

L17E is an attenuated cationic amphiphilic lytic (ACAL) peptide that can be used to deliver a variety of macromolecules, including proteins, antibodies, and DNA nanostructures. L17E inserts and cleaves the membrane structure through electrostatic interaction, enabling intracellular escape. The efficiency of L17E-mediated delivery is strongly correlated with the expression level of KCNN4 (the gene encoding the calcium-activated potassium channel KCa3.1). L17E also promotes the cellular uptake of macromolecules by inducing micropinocytosis. L17E can be further optimized and improved through dimerization strategies and in combination with other delivery systems, such as nuclear localization signal peptides and cell membrane-coated nanoparticles .
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Isotocin
Isotocin
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Referencia número: HY-P4184
No. CAS: 550-21-0
Synonyms: (Ser4,Ile8)-Oxytocin
Target:  

Endogenous Metabolite Aminopeptidase

Áreas de investigación:  

Neurological Disease

Isotocin is the homologue of mammalian oxytocin in teleost fish, belonging to the category of neurotransmitters/neuromodulators and peripheral hormones. Isotocin exerts biological effects by binding to its homologous isotocin receptor (with EC50 = 1.58e-10 mol/L in gilthead seabream) and specific G-protein-coupled receptor subtypes. Isotocin promotes paternal behavior in cichlids, regulates the expression of Foxi3a and P63, thereby controlling the differentiation of ionocyte progenitor cells and the proliferation of epidermal stem cells, and modulates whole-body ion content in zebrafish embryos. Isotocin regulates social and reproductive behaviors, synchronizes the reproductive cycles of teleost fish, and its neuronal phenotypes can be used to classify the types of reproductive systems in cichlids .
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Isotocin acetate
Isotocin acetate
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Referencia número: HY-P4184A
Synonyms: (Ser4,Ile8)-Oxytocin acetate
Target:  

Endogenous Metabolite Aminopeptidase

Áreas de investigación:  

Neurological Disease

Isotocin acetate is the homologue of mammalian oxytocin in teleost fish, belonging to the category of neurotransmitters/neuromodulators and peripheral hormones. Isotocin acetate exerts biological effects by binding to its homologous Isotocin acetate receptor (with EC50 = 1.58e-10 mol/L in gilthead seabream) and specific G-protein-coupled receptor subtypes. Isotocin acetate promotes paternal behavior in cichlids, regulates the expression of Foxi3a and P63, thereby controlling the differentiation of ionocyte progenitor cells and the proliferation of epidermal stem cells, and modulates whole-body ion content in zebrafish embryos. Isotocin acetate regulates social and reproductive behaviors, synchronizes the reproductive cycles of teleost fish, and its neuronal phenotypes can be used to classify the types of reproductive systems in cichlids .
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C12-iE-DAP
C12-iE-DAP
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Referencia número: HY-P5524
No. CAS: 1269619-57-9
Synonyms: Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid; γ-D-glutamyl-meso-diaminopimelic acid
Target:  

NOD-like Receptor (NLR) p38 MAPK NF-κB Toll-like Receptor (TLR)

Áreas de investigación:  

Inflammation/Immunology Cancer

C12-iE-DAP (Lauroyl-γ-D-glutamyl-meso-diaminopimelic acid) is a highly potent and selective NOD1 agonist, with an EC50 of 0.027 nM in HEK-Blue cells expressing human NOD1. C12-iE-DAP activates the NOD1/RIPK2 signaling pathway and its downstream p38 MAPK and NF-κB, induces the expression of inflammatory mediators such as IL6 and IL8, and exerts synergistic effects with TLR4, Dectin-1 or Mincle signaling. C12-iE-DAP can be used in studies related to vascular inflammation, tumor metastasis and neuroinflammation .
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TP4 (Nile tilapia piscidin)
TP4 (Nile tilapia piscidin)
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Referencia número: HY-P5557
No. CAS: 1429184-62-2
Target:  

Bacterial Necroptosis

Áreas de investigación:  

Infection Inflammation/Immunology

TP4 (Nile tilapia piscidin) is an orally active amphipathic α-helical cationic antimicrobial peptide. TP4 (Nile tilapia piscidin) exerts broad-spectrum bactericidal activity against Gram-positive and Gram-negative bacteria by disrupting cell membrane structures, and also exhibits certain hemolytic activity. TP4 (Nile tilapia piscidin) regulates the innate immune system and enhances the expression of lysozymes, cytokines and antioxidant enzymes to resist bacterial infection. TP4 (Nile tilapia piscidin) also stimulates the proliferation of keratinocytes and fibroblasts, and significantly promotes the healing of wounds infected with MRSA. TP4 (Nile tilapia piscidin) can be used in research related to bacterial infection, peritonitis, wound healing and other fields .
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