9030-66-4
Chemical Structure
Glycerol kinase, microorganism
Synonym(s): GyK
- CAS No.: 9030-66-4
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Glycerol kinase, microorganism]
Biological Activity: Glycerol kinase, microorganism (GyK) acts as a NR4A1 inhibitor with enzymatic activity. It directly binds to and inhibits the transcription factor NR4A1, thereby negatively regulating hepatic gluconeogenesis and reducing blood glucose levels. Glycerol kinase, microorganism positively regulates UCP1 expression via partial dependence on the β-adrenergic receptor-cAMP-CREB pathway, promotes browning of white adipose tissue and thermogenesis, and further modulates intracellular fatty acid composition and energy metabolism. In diabetic mouse models, overexpression of Glycerol kinase effectively antagonizes NR4A1-induced hyperglycemia, demonstrating potential for improving glucose homeostasis. Glycerol kinase, microorganism can be used for studies on diabetes and obesity[1][2].
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Glycerol kinase, microorganism | 98.00% | Glycerol kinase, microorganism (GyK) acts as a NR4A1 inhibitor with enzymatic activity. It directly binds to and inhibits the transcription factor NR4A1, thereby negatively regulating hepatic gluconeogenesis and reducing blood glucose levels. Glycerol kinase, microorganism positively regulates UCP1 expression via partial dependence on the β-adrenergic receptor-cAMP-CREB pathway, promotes browning of white adipose tissue and thermogenesis, and further modulates intracellular fatty acid composition and energy metabolism. In diabetic mouse models, overexpression of Glycerol kinase effectively antagonizes NR4A1-induced hyperglycemia, demonstrating potential for improving glucose homeostasis. Glycerol kinase, microorganism can be used for studies on diabetes and obesity. | ||||||||||||||||||||
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Glycerol kinase, Cellulomonas sp. | Glycerol kinase, Cellulomonas sp. (EC 2.7.1.30) is a bacterial sugar kinase, is often used in biochemical studies. Glycerol kinase, Cellulomonas sp. catalyzes the first step of glycerol metabolism by transforming the triol into glycerol-3-P (G3P). Glycerol kinase, Cellulomonas sp. is crucial for regulating channel/facilitator-independent uptake of glycerol into the cell. | |||||||||||||||||||||
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Glycerol kinase, Flavobacterium meningosepticum | Glycerol kinase, Flavobacterium meningosepticum (GyK, Flavobacterium meningosepticum) is a thermostable glycerol kinase isolated from Flavobacterium meningosepticum. Glycerol kinase, Flavobacterium meningosepticum catalyzes the first step in glycerol metabolism by converting triol to glycerol-3-p (G3P). Glycerol kinase, Flavobacterium meningosepticum is essential for regulating glycerol uptake in cells that is independent of channels or facilitators and is useful for biochemical studies. | |||||||||||||||||||||
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- [1]. Miao L, et al. Glycerol kinase interacts with nuclear receptor NR4A1 and regulates glucose metabolism in the liver. FASEB J. 2019;33(6):6736-6747. [Content Brief]
- [2]. Iwase M, et al. Glycerol kinase stimulates uncoupling protein 1 expression by regulating fatty acid metabolism in beige adipocytes. J Biol Chem. 2020;295(20):7033-7045. [Content Brief]
