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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
340 Results for "
HeL
" in MedChemExpress (MCE) Product Catalog:
Products (340)
340 Results for "HeL" in MCE Product Catalog:
Cat. No.: HY-189635
Target:
Research Areas:
NS3-IN-2 is a dual-target inhibitor targeting both NS2B‑NS3pro and NS3hel of West Nile virus (WNV). NS3-IN-2 inhibits the enzymatic activity of NS2B‑NS3pro toward polypeptide substrates in a non-competitive manner; for NS3hel, the compound exhibits a non-competitive inhibition mode with respect to ATP and competitive inhibition with respect to the dsDNA substrate. In biochemical assays, NS3-IN-2 has an IC50 = 4.4 μM against NS2B‑NS3pro and an IC50 = 24.0 μM against NS3hel helicase activity. NS3-IN-2 reduces WNV viral replication and exhibits cytotoxicity in hepatoma cells. NS3-IN-2 can be used for research on West Nile virus infection .
Cat. No.: HY-172566
Synonyms: 1-Myristyl LPA
Target:
Research Areas:
1-Myristyl-2-hydroxy-sn-glycero-3-PA (1-Myristyl LPA) is a lysophosphatidic acid derivative. 1-Myristyl-2-hydroxy-sn-glycero-3-PA can increase intracellular calcium concentration in HEL cells .
Category:
Target:
Cat. No.: HY-P80693A
Synonyms: GR; HeL-75; HeL-S-122m
Cat. No.: HY-179687
CAS No.: 3108318-77-7
Research Areas:
JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. JAK2-IN-18 can inhibit JAK-STAT signaling and shows an IC50 of <100 nM for pSTAT5 in HEL9217 cells. JAK2-IN-18 can inhibit the proliferation of abnormally proliferating myeloid cells and can be used for the research of myeloproliferative disorders, such as essential thrombocythemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
