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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
53 Results for "
ror1
" in MedChemExpress (MCE) Product Catalog:
Products (53)
53 Results for "ror1" in MCE Product Catalog:
Cat. No.: HY-P704864
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ror1; Neurotrophic Tyrosine Kinase, Receptor-Related 1; Prev. NTRKR1; DJ537F10.1; Inactive Tyrosine-Protein Kinase Transmembrane Receptor ror1; Receptor Tyrosine Kinase Like Orphan Receptor 1; ror1 Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-P72410
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ror1; Neurotrophic Tyrosine Kinase, Receptor-Related 1; Prev. NTRKR1; DJ537F10.1; Inactive Tyrosine-Protein Kinase Transmembrane Receptor ror1; Receptor Tyrosine Kinase Like Orphan Receptor 1; ror1 Protein
Species:
Human
Source:
HEK293
Cat. No.: HY-P11859
Research Areas:
Cat. No.: HY-P992376
Synonyms: NBE-002 Antibody
Cat. No.: HY-177109
CAS No.: 2765612-38-0
Target:
Research Areas:
BL20-MMAE is an antibody-drug conjugate targeting ROR1, which is formed by conjugating an anti-ROR1 antibody with the Auristatin payload MMAE (HY-15162) via a BL20 linker [1].
Cat. No.: HY-160806A
Target:
Research Areas:
(5-Cl)-Exatecan TFA is a derivative of Exatecan (HY-13631) and a DNA topoisomerase inhibitor. (5-Cl)-Exatecan TFA serves as the cytotoxic payload component in antibody-drug conjugates (ADC) targeting ROR1-positive cancers. (5-Cl)-Exatecan TFA is applicable for the research of ROR1-positive cancers [1].
Cat. No.: HY-P73390
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ror1; Neurotrophic Tyrosine Kinase, Receptor-Related 1; Prev. NTRKR1; DJ537F10.1; Inactive Tyrosine-Protein Kinase Transmembrane Receptor ror1; Receptor Tyrosine Kinase Like Orphan Receptor 1; ror1 Protein
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P11858
Research Areas:
Cat. No.: HY-183031
CAS No.: 3059866-62-2
Target:
Research Areas:
BrAA-glycine-BG-PAB-Exatecan (Compound LD-11) is an Drug-Linker Conjugates for ADC, consisting of Exatecan (HY-13631) and a linker. BrAA-glycine-BG-PAB-Exatecan can be conjugated with anti-ROR1 antibodies to form an ADC [1].
Cat. No.: HY-P992337
Cat. No.: HY-RS12126
Target:
Research Areas:
RORA Human Pre-designed siRNA Set A contains three designed siRNAs for RORA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12127
Target:
Research Areas:
Rora Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rora gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-117947
CAS No.: 1809336-19-3
Target:
Research Areas:
(R)-OR-S1 is an isomer of OR-S1. The dual ZH1/2 inhibitors OR-S1 and OR-S2 exhibit strong inhibitory activity against both EZH1 and EZH2. OR-S1 and OR-S2 are highly selective methyltransferase inhibitors against EZH1 and EZH2, and they have very similar molecular features. Therefore, we investigated the effect of OR-S1 on acute myeloid leukemia (AML). We found that OR-S1 was able to induce cell differentiation and apoptosis in AML cells. These findings encouraged us to investigate whether functional LT-HSCs could survive PRC2-targeted therapy with OR-S1 or OR-S1 combined with cytarabine. The results showed that OR-S1 did not cause significant myelosuppression, and BM cells treated with the combination therapy were able to undergo normal hematopoiesis even 4 months after treatment. Therefore, temporary inhibition of EZH1 and EZH2 is clinically tolerable, making this combination therapy suitable for AML patients. AML is generally believed to originate from myeloid progenitor cells that inherit a large number of biological properties.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
