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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
64 Results for "
RAR-beta
" in MedChemExpress (MCE) Product Catalog:
Products (64)
64 Results for "RAR-beta" in MCE Product Catalog:
Cat. No.: HY-B0091S
CAS No.: 1276433-89-6
Cat. No.: HY-B0091R
CAS No.: 106685-40-9
Synonyms: CD271 (Standard)
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Adapalene (Standard) is the analytical standard of Adapalene. This product is intended for research and analytical applications. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity .
Cat. No.: HY-15682R
CAS No.: 71441-28-6
Synonyms: Ro 13-7410 (Standard); Arotinoid acid (Standard); AGN191183 (Standard)
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TTNPB (Standard) is the analytical standard of TTNPB. This product is intended for research and analytical applications. TTNPB is a highly potent RAR agonist. Competitive binding assays using human RARs yield IC50s of α=5.1 nM, β= 4.5 nM, and γ=9.3 nM, respectively.
Cat. No.: HY-14649S5
CAS No.: 154461-49-1
Synonyms: Vitamin A acid-d3; all-trans-Retinoic acid-d3; ATRA-d3
Cat. No.: HY-14649S6
CAS No.: 3041101-53-2
Synonyms: Vitamin A acid-d3-1; all-trans-Retinoic acid-d3-1; ATRA-d3-1
Cat. No.: HY-RS11672
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RARB Human Pre-designed siRNA Set A contains three designed siRNAs for RARB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-14171R
CAS No.: 153559-49-0
Synonyms: LGD1069 (Standard)
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Bexarotene (Standard) is the analytical standard of Bexarotene. This product is intended for research and analytical applications. Bexarotene (LGD1069) is a high-affinity and selective retinoid X receptors (RXR) agonist with EC50s of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ, respectively. Bexarotene shows limited affinity for RAR receptors (EC50 >10000 nM) . Bexarotene can be used for the research of cutaneous T-cell lymphoma.
Cat. No.: HY-14171S2
Synonyms: LGD1069-13C6
Cat. No.: HY-15340R
CAS No.: 153559-76-3
Synonyms: LG268 (Standard)
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LG100268 (Standard) is the analytical standard of LG100268. This product is intended for research and analytical applications. LG100268 (LG268) is a potent, selective and orally active retinoid X receptor (RXR) agonist with EC50 values of 4 nM, 3 nM, and 4 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 displays >1000-fold selectivity for RXR over RAR, the Ki values are 3.4 nM, 6.2 nM and 9.2 nM for RXR-α, RXR-β, and RXR-γ, respectively . LG100268 activates RXR homodimers to induce transcriptional activation. LG100268 can be used for the study of lung carcinogenesisy .
Cat. No.: HY-W777169
CAS No.: 1185030-01-6
Synonyms: LGD1069-13C4
Cat. No.: HY-105689R
CAS No.: 166977-57-7
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AGN 192870 (Standard) is the analytical standard of AGN 192870 (HY-105689). This product is intended for research and analytical applications. AGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC50s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism . AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-100608R
CAS No.: 166977-43-1
Synonyms: BMS-189453 (Standard)
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BMS453 (Standard) is the analytical standard of BMS453 (HY-100608). This product is intended for research and analytical applications. BMS453 (BMS-189453), a synthetic retinoid, is a RARβ agonist and a RARα/RARγ antagonist. BMS453 inhibits breast cell growth predominantly through the induction of active TGFβ .
Cat. No.: HY-108530R
CAS No.: 345952-44-5
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MM11253 (Standard) is the analytical standard of MM11253 (HY-108530). This product is intended for research and analytical applications. MM11253 is a potent and selective RARγ antagonist with an IC50 of 44 nM. MM11253 has lower inhibition of RARα, RARβ and RXRα. MM11253 blocks the growth inhibitory effects of RARγ-selective agonists .
Cat. No.: HY-167262
CAS No.: 156691-86-0
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AGN-191659 is an orally active RAR/RXR agonist with EC50 values of 11 nM, 23 nM, and 37 nM for RXRα, RARβ, and RARγ, respectively. AGN-191659 activates RXRα, RARβ and RARγ to induce gene transcription. AGN-191659 induces tissue transglutaminase activity, inhibits ornithine decarboxylase activity induced by tumor promoters, and suppresses chondrogenesis. AGN-191659 reverses basic fibroblast growth factor-induced endothelial cell proliferation. AGN-191659 induces hypertriglyceridemia in rat models. AGN-191659 inhibits total heparin-releasable lipase activity. AGN-191659 can be used in research related to promyelocytic leukemia and hypertriglyceridemia .
Cat. No.: HY-100256S
Synonyms: CD5789-d4
Cat. No.: HY-183405
CAS No.: 143984-56-9
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CD2019 is a selective retinoic acid receptor β (RARβ) agonist, with a Kd value of 26 nM for RARβ and an AC50 value of 3.8 nM for human RARβ. CD2019 regulates downstream biological effects via the PI3K signaling pathway. CD2019 suppresses squamous metaplasia, inhibits squamous differentiation markers, maintains pseudostratified epithelial structure, induces neurite and axon growth, and promotes functional recovery; it exhibits cytotoxicity at higher concentrations and reduces endogenous retinol levels. CD2019 can be used in studies related to squamous metaplasia, spinal cord injury and embryonic malformations .
Cat. No.: HY-111573R
CAS No.: 1952276-71-9
Synonyms: C286 (Standard)
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KCL-286 (Standard) is the analytical standard of KCL-286 (HY-111573). This product is intended for research and analytical applications. KCL-286 (C286) is an orally active and brain-penetrant retinoic acid receptor (RAR) β2 agonist (EC50 = 1.9 nM). KCL-286 targets RARβ2 with good selectivity over RAR α (EC50 = 26 nM) and RAR γ (EC50 = 11 nM). KCL-286 activates RARβ2 in the injured neurons. KCL-286 induces axonal regeneration of both spinal and sensory nerves through the inhibitory environment of the CNS, modulates neuroinflammation and extracellular matrix molecules. KCL-286 can modulate the expression of CSPGs by neuronal secretion of decorin which promotes myelination and aids axonal growth. KCL-286 can be studied in research for area such as spinal cord injury and traumatic nerve injury .
Cat. No.: HY-W752012
Synonyms: CD271-13C6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
