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Cat. No.: HY-120130

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BMS-948

BMS-948 is a RARβ-selective transcriptional agonist with an EC₅₀ of 0.1 μM. BMS-948 is used in the research of tumor diseases, embryonic development and tissue remodeling.

For research use only. We do not sell to patients.

CAS No.: 168901-49-3
Formula: C₂₄H₁₇NO₃
Molecular Weight:367.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-948 Chemical Structure

CAS No.: 168901-49-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

BMS-948 is a RARβ-selective transcriptional agonist with an EC₅₀ of 0.1 μM. BMS-948 is used in the research of tumor diseases, embryonic development and tissue remodeling^[1].

IC₅₀ & Target

RXRβ

0.1 μM (EC₅₀)

All RAR/RXR Isoforms :

In Vitro

BMS-948 acts as a fully selective agonist of RARβ in HeLa cells, with an EC₅₀ of 0.1 μM for RARβ-mediated transactivation, and exhibits extremely low activity against RARα and RARγ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 168901-49-3
Molecular Weight 367.40
Formula C₂₄H₁₇NO₃
SMILES

O=C(O)C1=CC=C(C=C1)NC(=O)C2=CC=C3C=CC=C(C=4C=CC=CC4)C3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nadendla E, et al. An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist. PLoS One. 2015;10(5):e0123195. Published 2015 May 1. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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BMS-948

All RAR/RXR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

BMS-948 Related Classifications

HY-120130 Related Classifications