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Art. -Nr.: HY-120130

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BMS-948

BMS-948 is a RARβ-selective transcriptional agonist with an EC₅₀ of 0.1 μM. BMS-948 is used in the research of tumor diseases, embryonic development and tissue remodeling.

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CAS. Nr.: 168901-49-3
Formel: C₂₄H₁₇NO₃
Molecular Weight:367.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

BMS-948 Chemical Structure

CAS. Nr.: 168901-49-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

BMS-948 is a RARβ-selective transcriptional agonist with an EC₅₀ of 0.1 μM. BMS-948 is used in the research of tumor diseases, embryonic development and tissue remodeling^[1].

IC₅₀ & Target

RXRβ

0.1 μM (EC₅₀)

Alle RAR/RXR Isoform-spezifische Produkte anzeigen :

In Vitro

BMS-948 acts as a fully selective agonist of RARβ in HeLa cells, with an EC₅₀ of 0.1 μM for RARβ-mediated transactivation, and exhibits extremely low activity against RARα and RARγ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 168901-49-3
Molecular Weight 367.40
Formel C₂₄H₁₇NO₃
SMILES

O=C(O)C1=CC=C(C=C1)NC(=O)C2=CC=C3C=CC=C(C=4C=CC=CC4)C3=C2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Nadendla E, et al. An Unexpected Mode Of Binding Defines BMS948 as A Full Retinoic Acid Receptor β (RARβ, NR1B2) Selective Agonist. PLoS One. 2015;10(5):e0123195. Published 2015 May 1. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise

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BMS-948

Alle RAR/RXR Isoform-spezifische Produkte anzeigen